KEGG   DRUG: D04696Help
Entry
D04696                      Drug                                   

Name
Lestaurtinib (USAN/INN)
Formula
C26H21N3O4
Exact mass
439.1532
Mol weight
439.4626
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of tumors such as prostate and pancreatic carcinomas [selective inhibitor of tyrosine kinase]
Target
FLT3 inhibitor [HSA:2322] [KO:K05092];
janus kinase 2 (JAK2) inhibitor [HSA:3717] [KO:K04447];
neurotrophic tyrosine kinase, receptor, type 1 inhibitor [HSA:4914] [KO:K03176]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04062  Chemokine signaling pathway
hsa04630  Jak-STAT signaling pathway
hsa05200  Pathways in cancer
hsa05202  Transcriptional misregulation in cancer  
 
Interaction
Drug interaction
Structure map
Antineoplastics - protein kinases inhibitors
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    Fms-related tyrosine kinase 3 [HSA:2322] [KO:K05092]
     Lestaurtinib
      D04696  Lestaurtinib (USAN/INN)
 Protein kinases
  Tyrosine protein kinases
   JAK family
    Janus kinase 2 [HSA:3717] [KO:K04447]
     Lestaurtinib
      D04696  Lestaurtinib (USAN/INN)
   Trk family
    NTRK1 [HSA:4914] [KO:K03176]
     Lestaurtinib
      D04696  Lestaurtinib (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
111358-88-4
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        33
            1   C8y C    24.3753  -25.7760
            2   C8y C    24.3735  -27.1603
            3   C8y C    25.5714  -27.8540
            4   C8y C    26.7713  -27.1635
            5   C8y C    26.7731  -25.7791
            6   C8y C    25.5751  -25.0854
            7   N4y N    27.8030  -24.8542
            8   C8y C    27.2417  -23.5888
            9   C8y C    25.8647  -23.7317
            10  C8y C    25.8575  -29.2085
            11  C8y C    27.2341  -29.3550
            12  N4y N    27.7988  -28.0911
            13  C8x C    27.8063  -22.3249
            14  C8x C    26.9941  -21.2039
            15  C8x C    25.6171  -21.3468
            16  C8x C    25.0525  -22.6107
            17  C8x C    25.0424  -30.3273
            18  C8x C    25.6037  -31.5927
            19  C8x C    26.9803  -31.7392
            20  C8x C    27.7955  -30.6204
            21  C5x C    23.0593  -25.3465
            22  N1x N    22.2442  -26.4654
            23  C1x C    23.0564  -27.5863
            24  O5x O    22.6370  -24.0411
            25  C1y C    29.1949  -25.1514
            26  C1z C    29.1914  -27.7976
            27  O2x O    29.6260  -26.4832
            28  C1a C    30.1217  -28.8381
            29  C1x C    30.5316  -25.5114
            30  C1z C    30.5290  -27.4410
            31  C1b C    31.6309  -28.2888
            32  O1a O    31.4502  -29.6486
            33  O1a O    31.8667  -27.0845
BOND        40
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    6   9 1
            11    3  10 1
            12   10  11 1
            13   11  12 1
            14    4  12 1
            15    8  13 2
            16   13  14 1
            17   14  15 2
            18   15  16 1
            19    9  16 2
            20   10  17 2
            21   17  18 1
            22   18  19 2
            23   19  20 1
            24   11  20 2
            25    1  21 1
            26   21  22 1
            27   22  23 1
            28    2  23 1
            29   21  24 2
            30    7  25 1
            31   12  26 1
            32   25  27 1
            33   26  27 1
            34   26  28 1 #Down
            35   25  29 1
            36   26  30 1
            37   29  30 1
            38   30  31 1
            39   31  32 1
            40   30  33 1 #Up

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