KEGG   DRUG: D04721Help
Entry
D04721                      Drug                                   

Name
Levotofisopam (USAN/INN)
Formula
C22H26N2O4
Exact mass
382.1893
Mol weight
382.4528
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anxiolytic;
Autonomic instability
Comment
See Tofisopam [DR:D01254]
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site)
     Levotofisopam
      D04721  Levotofisopam (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
82059-51-6
PubChem: 
LigandBox: 
KCF data Show

ATOM        28
            1   C2y C    10.2652  -15.3773
            2   C8y C     9.4208  -14.2647
            3   C8y C     9.7569  -12.9042
            4   C1y C    11.0214  -12.3245
            5   N2x N    11.6748  -15.4026
            6   C2y C    12.2783  -12.9485
            7   N2x N    12.5656  -14.3210
            8   C8x C     8.7470  -11.9331
            9   C8y C     7.4014  -12.3223
            10  C8y C     7.0653  -13.6828
            11  C8x C     8.0751  -14.6536
            12  C1a C    13.3253  -12.0115
            13  O2a O     6.3922  -11.3519
            14  C1a C     5.0473  -11.7407
            15  C1a C     4.7112  -13.1012
            16  O2a O     5.7203  -14.0715
            17  C1b C    11.0432  -10.9210
            18  C1a C    12.2796  -10.2325
            19  C8y C     9.5436  -16.5769
            20  C8x C     8.1436  -16.5769
            21  C8y C     7.4436  -17.7894
            22  C8y C     8.1436  -19.0018
            23  C8x C     9.5436  -19.0018
            24  C8x C    10.2436  -17.7894
            25  O2a O     6.0436  -17.7894
            26  C1a C     5.3436  -19.0019
            27  C1a C     6.0436  -20.2143
            28  O2a O     7.4436  -20.2142
BOND        30
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 2
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    6  12 1
            14    9  13 1
            15   13  14 1
            16   15  16 1
            17   10  16 1
            18    4  17 1 #Down
            19   17  18 1
            20    1  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   19  24 1
            27   21  25 1
            28   25  26 1
            29   27  28 1
            30   22  28 1

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