KEGG   DRUG: Lisdexamfetamine dimesylate
Entry
D04747                      Drug                                   
Name
Lisdexamfetamine dimesylate (USAN);
Lisdexamfetamine mesilate (JAN);
Vyvanse (TN);
Elvanse (TN)
Product
VYVANSE (Takeda Pharmaceuticals America)
  Generic
LISDEXAMFETAMINE DIMESYLATE (Alvogen), LISDEXAMFETAMINE DIMESYLATE (Amneal Pharmaceuticals LLC), LISDEXAMFETAMINE DIMESYLATE (Apotex Corp.), LISDEXAMFETAMINE DIMESYLATE (Ascent Pharmaceuticals), LISDEXAMFETAMINE DIMESYLATE (Ascent Pharmaceuticals), LISDEXAMFETAMINE DIMESYLATE (Bryant Ranch Prepack), LISDEXAMFETAMINE DIMESYLATE (Hikma Pharmaceuticals USA), LISDEXAMFETAMINE DIMESYLATE (Lannett Company), LISDEXAMFETAMINE DIMESYLATE (Mylan Pharmaceuticals), LISDEXAMFETAMINE DIMESYLATE (Novadoz Pharmaceuticals LLC), LISDEXAMFETAMINE DIMESYLATE (Rhodes Pharmaceuticals), LISDEXAMFETAMINE DIMESYLATE (Solco Healthcare US), LISDEXAMFETAMINE DIMESYLATE (SpecGx LLC), LISDEXAMFETAMINE DIMESYLATE (Sun Pharmaceutical Industries)
Formula
C15H25N3O. (CH4SO3)2
Exact mass
455.176
Mol weight
455.5898
Structure
Remark
Therapeutic category: 1179
ATC code: N06BA12
Chemical structure group: DG00973
Product (DG00973): D04747<JP/US>
Efficacy
Stimulant (central)
  Disease
Attention deficit hyperactivity disorder [DS:H01895]
Binge eating disorder [DS:H01703]
Comment
Treatment of attention deficit hyperactivity disorder (ADHD)
Active form of prodrug: Dextroamphetamine [DR:D03740]
Target
SLC6A2 (NAT1) [HSA:6530] [KO:K05035]
SLC6A3 (DAT1) [HSA:6531] [KO:K05036]
  Pathway
hsa04721  Synaptic vesicle cycle
hsa04728  Dopaminergic synapse
Interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06B PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
    N06BA Centrally acting sympathomimetics
     N06BA12 Lisdexamfetamine
      D04747  Lisdexamfetamine dimesylate (USAN) <JP/US>
USP drug classification [BR:br08302]
 Central Nervous System Agents
  Attention Deficit Hyperactivity Disorder Agents, Amphetamines
   Lisdexamfetamine
    D04747  Lisdexamfetamine dimesylate (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   117  Psychotropics
    1179  Others
     D04747  Lisdexamfetamine dimesylate (USAN); Lisdexamfetamine mesilate (JAN)
Target-based classification of drugs [BR:br08310]
 Transporters
  Solute carrier family
   SLC6
    SLC6A2 (NAT1)
     D04747  Lisdexamfetamine dimesylate (USAN) <JP/US>
    SLC6A3 (DAT1)
     D04747  Lisdexamfetamine dimesylate (USAN) <JP/US>
New drug approvals in the USA [br08319.html]
 New molecular entities and new therapeutic biological products
  D04747
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D04747
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D04747
Prodrugs [br08324.html]
 DG00973
Other DBs
CAS: 608137-33-3
PubChem: 47206566
LigandBox: D04747
KCF data

ATOM        29
            1   C8x C     1.7500   -5.6700
            2   C8x C     1.7500   -7.0700
            3   C8x C     2.9624   -7.7700
            4   C8x C     4.1749   -7.0700
            5   C8y C     4.1749   -5.6700
            6   C8x C     2.9624   -4.9700
            7   C1b C     5.4060   -4.9590
            8   C1c C     6.6112   -5.6547
            9   N1b N     7.7935   -4.9719
            10  C1a C     6.6116   -7.0696
            11  C5a C     8.9875   -5.6612
            12  C1c C    10.1754   -4.9752
            13  O5a O     8.9877   -7.0697
            14  C1b C    11.3665   -5.6629
            15  C1b C    12.5559   -4.9761
            16  C1b C    13.7462   -5.6634
            17  C1b C    14.9361   -4.9763
            18  N1a N    16.1262   -5.6635
            19  N1a N    10.1755   -3.5702
            20  S4a S    22.2859   -5.9458
            21  C1a C    20.8827   -5.9458
            22  O1d O    23.6891   -5.9458
            23  O1d O    22.2859   -4.5426
            24  O1d O    22.2859   -7.3491
            25  S4a S    22.2859   -5.9458
            26  C1a C    20.8827   -5.9458
            27  O1d O    23.6891   -5.9458
            28  O1d O    22.2859   -4.5426
            29  O1d O    22.2859   -7.3491
BOND        27
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    8  10 1 #Up
            11    9  11 1
            12   11  12 1
            13   11  13 2
            14   12  14 1
            15   14  15 1
            16   15  16 1
            17   16  17 1
            18   17  18 1
            19   12  19 1 #Up
            20   20  21 1
            21   20  22 1
            22   20  23 2
            23   20  24 2
            24   25  26 1
            25   25  27 1
            26   25  28 2
            27   25  29 2
BRACKET     1    18.9700   -7.9100   18.9700   -3.5700
            1    25.2000   -3.5700   25.2000   -7.9100
            1  2
 ORIGINAL  1   20  21  22  23  24
 REPEAT    1   25  26  27  28  29

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