KEGG   DRUG: Lixivaptan
Entry
D04752                      Drug                                   
Name
Lixivaptan (USAN/INN)
Formula
C27H21ClFN3O2
Exact mass
473.1306
Mol weight
473.9259
Structure
Class
Cardiovascular agent
 DG01506  Arginine vasopressin receptor 2 (AVPR2) antagonist
Efficacy
Diuretic, Vasopressin V2 receptor antagonist
Comment
Treatment of nonhypovolemic hyponatremia
Target
AVPR2 [HSA:554] [KO:K04228]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04962  Vasopressin-regulated water reabsorption
Interaction
Brite
Drug groups [BR:br08330]
 Cardiovascular agent
  DG01506  Arginine vasopressin receptor 2 (AVPR2) antagonist
   D04752  Lixivaptan
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Vasopressin
    AVPR2
     D04752  Lixivaptan (USAN/INN)
Other DBs
CAS: 168079-32-1
PubChem: 47206571
LigandBox: D04752
KCF data

ATOM        34
            1   C1x C    13.2934   -9.4594
            2   C8y C    12.4513   -8.3498
            3   N4y N    12.7865   -6.9930
            4   C1x C    14.0475   -6.4149
            5   N1y N    14.6992   -9.4846
            6   C8y C    15.3011   -7.0372
            7   C8y C    15.5876   -8.4059
            8   C8x C    16.9188   -8.8430
            9   C8x C    17.9630   -7.9086
            10  C8x C    17.6766   -6.5399
            11  C8x C    16.3452   -6.1028
            12  O5a O    14.6557  -11.9091
            13  C5a C    15.3773  -10.7094
            14  C8x C    11.5997   -6.2549
            15  C8x C    10.5310   -7.1556
            16  C8x C    11.0573   -8.3102
            17  C8y C    16.7998  -10.7349
            18  C8y C    17.4998  -11.9474
            19  C8x C    18.8998  -11.9474
            20  C8y C    19.5998  -10.7349
            21  C8x C    18.8998   -9.5225
            22  C8x C    17.4998   -9.5225
            23  X   Cl   16.7899  -13.1766
            24  N1b N    20.9998  -10.7349
            25  C5a C    21.6891  -11.9287
            26  O5a O    21.0042  -13.1149
            27  C8y C    23.0891  -11.9287
            28  C8y C    23.7796  -13.1240
            29  C8x C    25.1796  -13.1237
            30  C8x C    25.8793  -11.9111
            31  C8y C    25.1888  -10.7157
            32  C8x C    23.7888  -10.7161
            33  C1a C    23.0997  -14.3023
            34  X   F    25.8938   -9.4940
BOND        38
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    6  11 2
            13   12  13 2
            14    5  13 1
            15    3  14 1
            16   14  15 2
            17   15  16 1
            18    2  16 2
            19   13  17 1
            20   17  18 2
            21   18  19 1
            22   19  20 2
            23   20  21 1
            24   21  22 2
            25   17  22 1
            26   18  23 1
            27   20  24 1
            28   24  25 1
            29   25  26 2
            30   25  27 1
            31   27  28 2
            32   28  29 1
            33   29  30 2
            34   30  31 1
            35   31  32 2
            36   27  32 1
            37   28  33 1
            38   31  34 1

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   KEGG BRITE (2)   
Drug (2)   
   KEGG DGROUP (1)   
   LigandBox (1)   
Chemical substance (1)   
   PubChem (1)   
Gene (2)   
   KEGG ORTHOLOGY (1)   
   KEGG GENES (1)   
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