KEGG   DRUG: Lotrafiban hydrochlorideHelp
Entry
D04785                      Drug                                   

Name
Lotrafiban hydrochloride (USAN)
Formula
C23H32N4O4. HCl
Exact mass
464.219
Mol weight
464.9855
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Cardiovascular agent
 DG01811  Fibrinogen receptor antagonist
Activity
Antithrombotic, Platelet aggregation inhibitor
Target
ITGA2B/ITGB3 [HSA:3674 3690] [KO:K06476 K06493]
  Pathway
Focal adhesion
ECM-receptor interaction
Brite
Target-based classification of drugs [BR:br08310]
 Others
  Cell adhesion molecules (CAMs)
   glycoprotein alpha IIb/beta3 (GPIIb/IIIa) receptor
    Lotrafiban
     D04785  Lotrafiban hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
179599-82-7
PubChem: 
LigandBox: 
KCF data Show

ATOM        32
            1   C8y C    32.4265  -17.6314
            2   N1x N    33.6829  -16.9334
            3   C1y C    34.9392  -17.4918
            4   C5x C    35.2882  -18.8877
            5   C8y C    32.1473  -18.9575
            6   N1y N    34.4506  -20.0045
            7   C1x C    33.0547  -20.0045
            8   C8x C    31.3796  -16.7240
            9   C8x C    30.0534  -17.1428
            10  C8y C    29.7742  -18.5388
            11  C8x C    30.8212  -19.4461
            12  C1a C    35.1486  -21.2608
            13  O5x O    36.6841  -19.0971
            14  C1b C    35.9861  -16.5844
            15  C6a C    37.3123  -17.0730
            16  O6a O    38.3592  -16.1657
            17  O6a O    37.5915  -18.4690
            18  C5a C    28.5642  -19.2430
            19  N1y N    27.3184  -18.5357
            20  O5a O    28.5741  -20.6310
            21  C1x C    27.3184  -17.1357
            22  C1x C    26.1060  -16.4357
            23  C1y C    24.8935  -17.1357
            24  C1x C    24.8935  -18.5357
            25  C1x C    26.1060  -19.2357
            26  C1y C    23.7071  -16.4507
            27  C1x C    23.7072  -15.0502
            28  C1x C    22.4947  -14.3502
            29  N1x N    21.2823  -15.0502
            30  C1x C    21.2823  -16.4507
            31  C1x C    22.4947  -17.1507
            32  X   Cl   39.7479  -20.0092
BOND        34
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     1   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    5  11 2
            13    6  12 1
            14    4  13 2
            15    3  14 1 #Up
            16   14  15 1
            17   15  16 1
            18   15  17 2
            19   10  18 1
            20   18  19 1
            21   18  20 2
            22   19  21 1
            23   21  22 1
            24   22  23 1
            25   23  24 1
            26   24  25 1
            27   19  25 1
            28   23  26 1
            29   26  27 1
            30   27  28 1
            31   28  29 1
            32   29  30 1
            33   30  31 1
            34   26  31 1

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