KEGG   DRUG: D04882Help
Entry
D04882                      Drug                                   

Name
Medazepam hydrochloride (USAN);
Nobrium (TN)
Formula
C16H15ClN2. HCl
Exact mass
306.0691
Mol weight
307.2176
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Tranquilizer [minor]
Remark
ATC code: 
Comment
withdrawal drag
Benzodiazepines
Target
GABAA-receptor (benzodiazepine binding site) agonist [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05181 K05184 K05185 K05186 K05189 K05192]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04727  GABAergic synapse  
 
Interaction
Drug interaction
Structure map
GABA-A receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05B ANXIOLYTICS
    N05BA Benzodiazepine derivatives
     N05BA03 Medazepam
      D04882  Medazepam hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   GABA-A
    GABAA-receptor (benzodiazepine binding site) [HSA:2554 2555 2556 2557 2558 2559 2560 2561 2562 2563 2564 2565 2566 2567 2568 55879] [KO:K05175 K05176 K05177 K05178 K05179 K05180 K05181 K05182 K05183 K05184 K05185 K05186 K05187 K05188 K05189 K05192]
     Medazepam [ATC:N05BA03]
      D04882  Medazepam hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
2898-11-5
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        20
            1   X   Cl   36.9447  -15.6399
            2   C2y C    32.4800  -15.5400
            3   C8y C    31.6400  -14.4200
            4   C8y C    31.9900  -13.0900
            5   N1y N    33.2500  -12.5300
            6   N2x N    33.8800  -15.5400
            7   C1x C    34.5100  -13.1600
            8   C1x C    34.7900  -14.4900
            9   C8x C    30.9400  -12.1100
            10  C8x C    29.6100  -12.5300
            11  C8y C    29.2600  -13.8600
            12  C8x C    30.3100  -14.8400
            13  X   Cl   27.9300  -14.2800
            14  C8y C    31.8500  -16.8000
            15  C8x C    30.4500  -16.8000
            16  C8x C    29.7500  -17.9900
            17  C8x C    30.4500  -19.2500
            18  C8x C    31.8500  -19.2500
            19  C8x C    32.5500  -17.9900
            20  C1a C    33.2500  -11.1300
BOND        21
            1     4   5 1
            2     2   6 2
            3     5   7 1
            4     3   4 1
            5     6   8 1
            6     2   3 1
            7     7   8 1
            8     4   9 2
            9     9  10 1
            10   10  11 2
            11   11  12 1
            12    3  12 2
            13   11  13 1
            14    2  14 1
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   18  19 1
            20   14  19 2
            21    5  20 1

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