KEGG   DRUG: Memantine hydrochlorideHelp
Entry
D04905                      Drug                                   

Name
Memantine hydrochloride (JAN/USAN);
Namenda (TN);
Memary (TN)
Product
  Generic
MEMANTINE (American Health Packaging), MEMANTINE HYDROCHLORIDE (Amneal Pharmaceuticals of New York), MEMANTINE HYDROCHLORIDE (AvKARE), MEMANTINE (Cardinal Health), MEMANTINE (Dr. Reddys Laboratories Limited), MEMANTINE (Major Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Mylan Institutional), MEMANTINE HYDROCHLORIDE (Mylan Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Ajanta Pharma Limited), MEMANTINE HYDROCHLORIDE (Alembic Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), MEMANTINE HYDROCHLORIDE (Aphena Pharma Solutions - Tennessee), MEMANTINE HYDROCHLORIDE (Aurobindo Pharma Limited), MEMANTINE HYDROCHLORIDE (Jubilant Cadista Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Lannett Company), MEMANTINE HYDROCHLORIDE (Lupin Pharmaceuticals), MEMANTINE HYDROCHLORIDE (Macleods Pharmaceuticals Limited), MEMANTINE HYDROCHLORIDE (Macleods Pharmaceuticals Limited), MEMANTINE HYDROCHLORIDE (Patrin Pharma), MEMANTINE HYDROCHLORIDE (PuraCap Pharmaceutical LLC), MEMANTINE HYDROCHLORIDE (Sun Pharma Global FZE), MEMANTINE HYDROCHLORIDE (Torrent Pharmaceuticals Limited), MEMANTINE HYDROCHLORIDE (Unichem Pharmaceuticals (USA)), MEMANTINE HYDROCHLORIDE (Upsher-Smith Laboratories), MEMANTINE HYDROCHLORIDE (Vivimed Labs Limited), MEMANTINE HYDROCHLORIDE (Wockhardt USA LLC.), MEMATINE HYDROCHLORIDE (Orchid Chemicals & Pharmaceuticals Limited)
Formula
C12H21N. HCl
Exact mass
215.1441
Mol weight
215.7628
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01498  NMDA receptor antagonist
Unclassified
 DG01968  Agents for Alzheimer-type dementia
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Nootropic, NMDA receptor antagonist
  Disease
Alzheimer's disease [DS:H00056]
Comment
Adamantane derivative
Target
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Glutamatergic synapse
Alzheimer's disease
Metabolism
Transporter: SLC22A2 [HSA:6582]
Interaction
Drug interaction
Structure map
Agents for Alzheimer-type dementia
N-Metyl-D-aspartic acid receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DX Other anti-dementia drugs
     N06DX01 Memantine
      D04905  Memantine hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Antidementia Agents
  N-methyl-D-aspartate (NMDA) Receptor Antagonist
   Memantine
    D04905  Memantine hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D04905  Memantine hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Glutamate-gated cation channels
   Glutamate (ionotropic), NMDA
    N-methyl-D-aspartate receptor
     Memantine
      D04905  Memantine hydrochloride (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 Transporter substrates
  SLC22A2
   Memantine
    D04905  Memantine hydrochloride (JAN/USAN)
Neurological agents [br08367.html]
 Anti-Alzheimer agents
  D04905
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D04905
BRITE hierarchy
Other DBs
CAS: 
41100-52-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        14
            1   C1x C    24.5248  -18.7456
            2   C1z C    24.5248  -20.1058
            3   C1x C    25.7055  -20.7858
            4   C1z C    26.8792  -20.1058
            5   C1x C    26.8792  -18.7456
            6   C1z C    25.7055  -18.0656
            7   C1x C    23.5563  -21.0675
            8   C1y C    24.9163  -21.0675
            9   C1x C    26.2284  -21.4178
            10  C1a C    28.1860  -20.4561
            11  C1a C    23.2060  -20.4561
            12  N1a N    25.7073  -16.7056
            13  C1x C    24.9096  -19.4326
            14  X   Cl   32.0600  -19.7400
BOND        15
            1     2   7 1
            2     1   2 1
            3     7   8 1
            4     2   3 1
            5     8   9 1
            6     9   4 1
            7     3   4 1
            8     4  10 1
            9     4   5 1
            10    2  11 1
            11    5   6 1
            12    6  12 1
            13    6   1 1
            14    8  13 1
            15    6  13 1

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