KEGG   DRUG: D04905Help
Entry
D04905                      Drug                                   

Name
Memantine hydrochloride (JAN/USAN);
Namenda (TN);
Memary (TN)
Product
Formula
C12H21N. HCl
Exact mass
215.1441
Mol weight
215.7628
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of Alzheimer's disease [DS:H00056]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
adamantane derivative
Target
N-methyl-D-aspartate receptor antagonist [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa05010  Alzheimer's disease  
 
Metabolism
Transporter: SLC22A2 [HSA:6582]
Interaction
Drug interaction
Structure map
Agents for Alzheimer-type dementia
N-Metyl-D-aspartic acid receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N06 PSYCHOANALEPTICS
   N06D ANTI-DEMENTIA DRUGS
    N06DX Other anti-dementia drugs
     N06DX01 Memantine
      D04905  Memantine hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Antidementia Agents
  N-methyl-D-aspartate (NMDA) Receptor Antagonist
   Memantine
    D04905  Memantine hydrochloride (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   119  Miscellaneous
    1190  Miscellaneous
     D04905  Memantine hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Glutamate-gated cation channels
   Glutamate (ionotropic), NMDA
    N-methyl-D-aspartate receptor
     Memantine
      D04905  Memantine hydrochloride (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
41100-52-1
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        14
            1   C1x C    24.5248  -18.7456
            2   C1z C    24.5248  -20.1058
            3   C1x C    25.7055  -20.7858
            4   C1z C    26.8792  -20.1058
            5   C1x C    26.8792  -18.7456
            6   C1z C    25.7055  -18.0656
            7   C1x C    23.5563  -21.0675
            8   C1y C    24.9163  -21.0675
            9   C1x C    26.2284  -21.4178
            10  C1a C    28.1860  -20.4561
            11  C1a C    23.2060  -20.4561
            12  N1a N    25.7073  -16.7056
            13  C1x C    24.9096  -19.4326
            14  X   Cl   32.0600  -19.7400
BOND        15
            1     2   7 1
            2     1   2 1
            3     7   8 1
            4     2   3 1
            5     8   9 1
            6     9   4 1
            7     3   4 1
            8     4  10 1
            9     4   5 1
            10    2  11 1
            11    5   6 1
            12    6  12 1
            13    6   1 1
            14    8  13 1
            15    6  13 1

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