| Entry |
|
|---|
| Name |
Memantine hydrochloride (JAN/USAN);
Namenda (TN);
Memary (TN)
|
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| Product |
|
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| Formula |
C12H21N. HCl
|
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| Exact mass |
215.1441
|
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| Mol weight |
215.7628
|
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| Structure |
     |
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| Activity |
Treatment of Alzheimer's disease [DS: H00056]
|
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| Remark |
Therapeutic category: ATC code: |
|---|
| Comment |
adamantane derivative
|
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| Target |
|
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| Pathway |
|
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| Metabolism |
Transporter: SLC22A2 [HSA: 6582]
|
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| Interaction |
|
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| Structure map |
| N-Metyl-D-aspartic acid receptor antagonists |
|
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
119 Miscellaneous
1190 Miscellaneous
D04905 Memantine hydrochloride (JAN/USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N06 PSYCHOANALEPTICS
N06D ANTI-DEMENTIA DRUGS
N06DX Other anti-dementia drugs
N06DX01 Memantine
D04905 Memantine hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
Antidementia Agents
N-methyl-D-aspartate (NMDA) Receptor Antagonist
Memantine
D04905 Memantine hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
Ion channels
Glutamate-gated cation channels
Glutamate (ionotropic), NMDA
N-methyl-D-aspartate receptor [HSA:2902 2903 2904 2905 2906] [KO:K05208 K05209 K05210 K05211 K05212]
Memantine [ATC:N06DX01]
D04905 Memantine hydrochloride (JAN/USAN)
 |
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| Other DBs |
CAS: 41100-52-1 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 14
1 C1x C 24.5248 -18.7456
2 C1z C 24.5248 -20.1058
3 C1x C 25.7055 -20.7858
4 C1z C 26.8792 -20.1058
5 C1x C 26.8792 -18.7456
6 C1z C 25.7055 -18.0656
7 C1x C 23.5563 -21.0675
8 C1y C 24.9163 -21.0675
9 C1x C 26.2284 -21.4178
10 C1a C 28.1860 -20.4561
11 C1a C 23.2060 -20.4561
12 N1a N 25.7073 -16.7056
13 C1x C 24.9096 -19.4326
14 X Cl 32.0600 -19.7400
BOND 15
1 2 7 1
2 1 2 1
3 7 8 1
4 2 3 1
5 8 9 1
6 9 4 1
7 3 4 1
8 4 10 1
9 4 5 1
10 2 11 1
11 5 6 1
12 6 12 1
13 6 1 1
14 8 13 1
15 6 13 1
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