KEGG   DRUG: D05014Help
Entry
D05014                      Drug                                   

Name
Mettreleptin (genetical recombination) (JAN);
Metreleptin (USAN/INN);
Metreleptin (TN);
Myalept (TN)
Product
Formula
C714H1167N191O221S6
Exact mass
16145.4275
Mol weight
16155.4429
Sequence
MVPIQKVQDD TKTLIKTIVT RINDISHTQS VSSKQKVTGL DFIPGLHPIL TLSKMDQTLA
VYQQILTSMP SRNVIQISND LENLRDLLHV LAFSKSCHLP WASGLETLDS LGGVLEASGY
STEVVALSRL QGSLQDMLWQ LDLSPGC (Disulfide bridge: 97-147)
  Type
Peptide
Activity
Treatment of obesity and related disorders [metabolic homeostasis regulator];
[DS:H00419]
Remark
Therapeutic category: 
Comment
leptin [CPD:C18188] analogue
N-methionylleptin (human)
Target
leptin receptor agonist [HSA:3953] [KO:K05062]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04080  Neuroactive ligand-receptor interaction
hsa04920  Adipocytokine signaling pathway  
 
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D05014  Mettreleptin (genetical recombination) (JAN); Metreleptin (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class I cytokine receptors (hematopoietin family receptors)
   leptin receptor
    Metreleptin
     D05014  Metreleptin (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
186018-45-1
PubChem: 

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