KEGG   DRUG: D05077Help
Entry
D05077                      Drug                                   

Name
Moricizine (USAN);
Moracizine (INN)
Formula
C22H25N3O4S
Exact mass
427.1566
Mol weight
427.5166
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiac depressant [anti-arrhythmic]
Remark
Same as: 
ATC code: 
Drug group: 
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Interaction
CYP induction: CYP1A2 [HSA:1544]
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C01 CARDIAC THERAPY
   C01B ANTIARRHYTHMICS, CLASS I AND III
    C01BG Other antiarrhythmics, class I and III
     C01BG01 Moracizine
      D05077  Moricizine (USAN); Moracizine (INN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Moracizine
      D05077  Moricizine (USAN); Moracizine (INN)
    voltage-gated sodium channel (SCN2A)
     Moracizine
      D05077  Moricizine (USAN); Moracizine (INN)
    voltage-gated sodium channel (SCN3A)
     Moracizine
      D05077  Moricizine (USAN); Moracizine (INN)
    voltage-gated sodium channel (SCN4A)
     Moracizine
      D05077  Moricizine (USAN); Moracizine (INN)
    voltage-gated sodium channel (SCN5A)
     Moracizine
      D05077  Moricizine (USAN); Moracizine (INN)
    voltage-gated sodium channel (SCN8A)
     Moracizine
      D05077  Moricizine (USAN); Moracizine (INN)
    voltage-gated sodium channel (SCN9A)
     Moracizine
      D05077  Moricizine (USAN); Moracizine (INN)
Cytochrome P450 interactions [BR:br08309]
 Inducers
  CYP1A2
   Moricizine
    D05077  Moricizine (USAN); Moracizine (INN)
BRITE hierarchy
Other DBs
CAS: 
31883-05-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        30
            1   C8y C    23.2514  -19.4836
            2   N1y N    22.0493  -18.7834
            3   C8y C    23.2514  -20.8840
            4   C8x C    24.4533  -18.7834
            5   C8y C    20.8298  -19.4836
            6   C5a C    22.0435  -17.3889
            7   S2x S    22.0493  -21.5843
            8   C8x C    24.4533  -21.5843
            9   C8y C    25.6671  -19.4836
            10  C8y C    20.8298  -20.8840
            11  C8x C    19.6161  -18.7834
            12  C1b C    23.2572  -16.6887
            13  O5a O    20.8240  -16.6887
            14  C8x C    25.6671  -20.8840
            15  N1b N    26.8808  -18.7776
            16  C8x C    19.6161  -21.5843
            17  C8x C    18.3966  -19.4836
            18  C1b C    23.2572  -15.2942
            19  C7a C    28.0945  -19.4719
            20  C8x C    18.3966  -20.8840
            21  N1y N    24.4709  -14.5880
            22  O7a O    29.3082  -18.7660
            23  O6a O    28.0945  -20.8783
            24  C1x C    25.6729  -15.2882
            25  C1x C    24.5350  -13.1876
            26  C1b C    30.5160  -19.4662
            27  C1x C    26.8867  -14.5823
            28  C1x C    25.6729  -12.4876
            29  C1a C    31.7296  -18.7602
            30  O2x O    26.8867  -13.1818
BOND        33
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 2
            10    5  11 1
            11    6  12 1
            12    6  13 2
            13    8  14 2
            14    9  15 1
            15   10  16 1
            16   11  17 2
            17   12  18 1
            18   15  19 1
            19   16  20 2
            20   18  21 1
            21   19  22 1
            22   19  23 2
            23   21  24 1
            24   21  25 1
            25   22  26 1
            26   24  27 1
            27   25  28 1
            28   26  29 1
            29   27  30 1
            30    7  10 1
            31    9  14 1
            32   17  20 1
            33   28  30 1

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