KEGG   DRUG: D05140Help
Entry
D05140                      Drug                                   

Name
Framycetin (INN);
Fradiomycin B;
Neomycin B;
FRM
Formula
C23H46N6O13
Exact mass
614.3123
Mol weight
614.6437
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Component of Neomycin [CPD:C00384]
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Aminoglycosides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D09 MEDICATED DRESSINGS
   D09A MEDICATED DRESSINGS
    D09AA Medicated dressings with antiinfectives
     D09AA01 Framycetin
      D05140  Framycetin (INN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AX Other nasal preparations
     R01AX08 Framycetin
      D05140  Framycetin (INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA07 Framycetin
      D05140  Framycetin (INN)
Risk category of Japanese OTC drugs [BR:br08312]
 Second-class OTC drugs
  Inorganic and organic chemicals
   Fradiomycin
    D05140  Framycetin (INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor
    Aminoglycosides
     Framycetin
      D05140  Framycetin (INN)
BRITE hierarchy
Other DBs
CAS: 
119-04-0
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        42
            1   C1y C    18.5833  -19.8269
            2   C1y C    18.5833  -21.2133
            3   C1y C    19.8310  -21.9065
            4   C1y C    21.0095  -21.2133
            5   C1y C    21.0095  -19.8269
            6   O2x O    19.8310  -19.1338
            7   O2a O    22.1879  -19.1338
            8   C1y C    24.4062  -17.9554
            9   C1y C    24.8221  -16.6383
            10  O2x O    23.7129  -15.8758
            11  C1y C    22.6038  -16.6383
            12  C1y C    23.0198  -17.9554
            13  O2a O    26.4855  -16.2224
            14  O1a O    26.9013  -18.9951
            15  C1y C    28.0797  -18.3019
            16  C1y C    29.2581  -18.9951
            17  C1x C    30.4365  -18.3019
            18  C1y C    30.4365  -16.9155
            19  C1y C    29.2581  -16.2224
            20  C1y C    28.0797  -16.9155
            21  N1a N    29.2581  -20.3815
            22  N1a N    31.6149  -16.2224
            23  O2a O    29.2581  -14.8360
            24  C1y C    30.4365  -14.1428
            25  O2x O    31.6149  -14.8360
            26  C1y C    32.7934  -14.1428
            27  C1y C    32.7934  -12.7564
            28  C1y C    31.6149  -12.0632
            29  C1y C    30.4365  -12.7564
            30  C1b C    34.0411  -14.7666
            31  N1a N    34.0411  -16.1530
            32  N1a N    29.1887  -12.0632
            33  O1a O    31.6149  -10.6768
            34  O1a O    34.0411  -11.9939
            35  C1b C    21.2868  -16.2224
            36  O1a O    25.2380  -19.1338
            37  O1a O    20.2469  -17.1928
            38  C1b C    17.4049  -19.1338
            39  O1a O    17.4049  -21.9065
            40  N1a N    22.1879  -21.9065
            41  O1a O    19.8310  -23.2929
            42  N1a N    16.1987  -19.8171
BOND        45
            1    25  26 1
            2    26  27 1
            3    27  28 1
            4    28  29 1
            5    29  24 1
            6    26  30 1 #Up
            7    15  14 1 #Down
            8    30  31 1
            9     5   7 1 #Down
            10   29  32 1 #Down
            11   28  33 1 #Up
            12    1   2 1
            13   27  34 1 #Down
            14    2   3 1
            15   11  35 1 #Up
            16   12   7 1 #Down
            17    3   4 1
            18    8  36 1 #Down
            19   15  16 1
            20   35  37 1
            21   16  17 1
            22    1  38 1 #Down
            23   17  18 1
            24    2  39 1 #Down
            25   18  19 1
            26    4  40 1 #Down
            27   19  20 1
            28    3  41 1 #Up
            29   20  15 1
            30    4   5 1
            31   16  21 1 #Up
            32    8   9 1
            33   18  22 1 #Up
            34    9  10 1
            35   19  23 1 #Down
            36   20  13 1 #Up
            37   10  11 1
            38   24  23 1 #Down
            39   11  12 1
            40   12   8 1
            41    5   6 1
            42    9  13 1 #Up
            43    6   1 1
            44   24  25 1
            45   38  42 1

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