KEGG   DRUG: D05140Help
Entry
D05140                      Drug                                   

Name
Framycetin (INN);
Fradiomycin B;
Neomycin B;
FRM
Formula
C23H46N6O13
Exact mass
614.3123
Mol weight
614.6437
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
Comment
Component of Neomycin [CPD:C00384]
Target
16S rRNA of 30S ribosomal subunit, protein synthesis inhibitor [KO:K01977]
  Pathway
ko03010  Ribosome  
 
Interaction
Drug interaction
Structure map
Aminoglycosides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A01 STOMATOLOGICAL PREPARATIONS
   A01A STOMATOLOGICAL PREPARATIONS
    A01AB Antiinfectives and antiseptics for local oral treatment
     A01AB08 Neomycin
      D05140  Framycetin (INN)
  A07 ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
   A07A INTESTINAL ANTIINFECTIVES
    A07AA Antibiotics
     A07AA01 Neomycin
      D05140  Framycetin (INN)
 B BLOOD AND BLOOD FORMING ORGANS
  B05 BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
   B05C IRRIGATING SOLUTIONS
    B05CA Antiinfectives
     B05CA09 Neomycin
      D05140  Framycetin (INN)
 D DERMATOLOGICALS
  D06 ANTIBIOTICS AND CHEMOTHERAPEUTICS FOR DERMATOLOGICAL USE
   D06A ANTIBIOTICS FOR TOPICAL USE
    D06AX Other antibiotics for topical use
     D06AX04 Neomycin
      D05140  Framycetin (INN)
  D09 MEDICATED DRESSINGS
   D09A MEDICATED DRESSINGS
    D09AA Medicated dressings with antiinfectives
     D09AA01 Framycetin
      D05140  Framycetin (INN)
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01G AMINOGLYCOSIDE ANTIBACTERIALS
    J01GB Other aminoglycosides
     J01GB05 Neomycin
      D05140  Framycetin (INN)
 R RESPIRATORY SYSTEM
  R01 NASAL PREPARATIONS
   R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE
    R01AX Other nasal preparations
     R01AX08 Framycetin
      D05140  Framycetin (INN)
  R02 THROAT PREPARATIONS
   R02A THROAT PREPARATIONS
    R02AB Antibiotics
     R02AB01 Neomycin
      D05140  Framycetin (INN)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA03 Neomycin
      D05140  Framycetin (INN)
     S01AA07 Framycetin
      D05140  Framycetin (INN)
  S02 OTOLOGICALS
   S02A ANTIINFECTIVES
    S02AA Antiinfectives
     S02AA07 Neomycin
      D05140  Framycetin (INN)
  S03 OPHTHALMOLOGICAL AND OTOLOGICAL PREPARATIONS
   S03A ANTIINFECTIVES
    S03AA Antiinfectives
     S03AA01 Neomycin
      D05140  Framycetin (INN)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   16S rRNA of 30S ribosomal subunit inhibitor [KO:K01977]
    Aminoglycosides
     Neomycin [ATC:A01AB08 A07AA01 B05CA09 D06AX04 J01GB05 R02AB01 S01AA03 S02AA07 S03AA01]
      D05140  Framycetin (INN)
BRITE hierarchy
Other DBs
CAS: 
119-04-0
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        42
            1   C1y C    18.5833  -19.8269
            2   C1y C    18.5833  -21.2133
            3   C1y C    19.8310  -21.9065
            4   C1y C    21.0095  -21.2133
            5   C1y C    21.0095  -19.8269
            6   O2x O    19.8310  -19.1338
            7   O2a O    22.1879  -19.1338
            8   C1y C    24.4062  -17.9554
            9   C1y C    24.8221  -16.6383
            10  O2x O    23.7129  -15.8758
            11  C1y C    22.6038  -16.6383
            12  C1y C    23.0198  -17.9554
            13  O2a O    26.4855  -16.2224
            14  O1a O    26.9013  -18.9951
            15  C1y C    28.0797  -18.3019
            16  C1y C    29.2581  -18.9951
            17  C1x C    30.4365  -18.3019
            18  C1y C    30.4365  -16.9155
            19  C1y C    29.2581  -16.2224
            20  C1y C    28.0797  -16.9155
            21  N1a N    29.2581  -20.3815
            22  N1a N    31.6149  -16.2224
            23  O2a O    29.2581  -14.8360
            24  C1y C    30.4365  -14.1428
            25  O2x O    31.6149  -14.8360
            26  C1y C    32.7934  -14.1428
            27  C1y C    32.7934  -12.7564
            28  C1y C    31.6149  -12.0632
            29  C1y C    30.4365  -12.7564
            30  C1b C    34.0411  -14.7666
            31  N1a N    34.0411  -16.1530
            32  N1a N    29.1887  -12.0632
            33  O1a O    31.6149  -10.6768
            34  O1a O    34.0411  -11.9939
            35  C1b C    21.2868  -16.2224
            36  O1a O    25.2380  -19.1338
            37  O1a O    20.2469  -17.1928
            38  C1b C    17.4049  -19.1338
            39  O1a O    17.4049  -21.9065
            40  N1a N    22.1879  -21.9065
            41  O1a O    19.8310  -23.2929
            42  N1a N    16.1987  -19.8171
BOND        45
            1    25  26 1
            2    26  27 1
            3    27  28 1
            4    28  29 1
            5    29  24 1
            6    26  30 1 #Up
            7    15  14 1 #Down
            8    30  31 1
            9     5   7 1 #Down
            10   29  32 1 #Down
            11   28  33 1 #Up
            12    1   2 1
            13   27  34 1 #Down
            14    2   3 1
            15   11  35 1 #Up
            16   12   7 1 #Down
            17    3   4 1
            18    8  36 1 #Down
            19   15  16 1
            20   35  37 1
            21   16  17 1
            22    1  38 1 #Down
            23   17  18 1
            24    2  39 1 #Down
            25   18  19 1
            26    4  40 1 #Down
            27   19  20 1
            28    3  41 1 #Up
            29   20  15 1
            30    4   5 1
            31   16  21 1 #Up
            32    8   9 1
            33   18  22 1 #Up
            34    9  10 1
            35   19  23 1 #Down
            36   20  13 1 #Up
            37   10  11 1
            38   24  23 1 #Down
            39   11  12 1
            40   12   8 1
            41    5   6 1
            42    9  13 1 #Up
            43    6   1 1
            44   24  25 1
            45   38  42 1

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