KEGG   DRUG: D05246Help
Entry
D05246                      Drug                                   

Name
Olmesartan (USAN/INN)
Formula
C24H26N6O3
Exact mass
446.2066
Mol weight
446.5016
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of hypertension [novel angiotensin (Ang II) antagonist]
Target
angiotensin II receptor type 1(AT1) antagonist [HSA:185] [KO:K04166]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04614  Renin-angiotensin system  
 
Metabolism
Transporter: SLCO1B1 [HSA:10599], SLCO1B3 [HSA:28234], ABCC2 [HSA:1244]
Interaction
Drug interaction
Structure map
Angiotensin receptor and endothelin receptor antagonists
Other map
Bile secretion
Brite
USP drug classification [BR:br08302]
 Cardiovascular Agents
  Angiotensin II Receptor Antagonists
   Olmesartan
    D05246  Olmesartan (USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Angiotensin
    angiotensin II stimulates angiotensin subtype 1 (AT1) receptor
     Olmesartan
      D05246  Olmesartan (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
144689-24-7
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        33
            1   C1d C    30.1124  -16.1644
            2   C8y C    29.4120  -14.9513
            3   O1a O    29.4120  -17.3776
            4   C6a C    27.3107  -16.1644
            5   O6a O    28.0112  -17.3776
            6   C8y C    28.0112  -14.9513
            7   C1b C    26.3656  -12.9132
            8   C8y C    25.1490  -13.6075
            9   N4y N    27.5753  -13.6198
            10  N5x N    29.8481  -13.6198
            11  C8y C    28.7116  -12.7933
            12  C8x C    23.9417  -12.8984
            13  C8x C    22.7250  -13.5926
            14  C8y C    22.7178  -14.9934
            15  C8x C    23.9275  -15.7000
            16  C8x C    25.1443  -15.0058
            17  C8y C    21.5012  -15.6877
            18  C8y C    20.2956  -14.9759
            19  C8x C    19.0790  -15.6703
            20  C8x C    19.1419  -17.0711
            21  C8x C    20.2815  -17.7776
            22  C8x C    21.4982  -17.0833
            23  C8y C    20.3062  -13.5751
            24  N5x N    21.4481  -12.7573
            25  N5x N    21.0251  -11.4219
            26  N5x N    19.6244  -11.4117
            27  N4x N    19.1816  -12.7405
            28  C1a C    31.0959  -15.1634
            29  C1a C    31.0959  -17.1516
            30  O6a O    25.9099  -16.1644
            31  C1b C    28.7116  -11.3925
            32  C1b C    27.4984  -10.6921
            33  C1a C    26.2851  -11.3925
BOND        36
            1    12  13 1
            2    13  14 2
            3    14  15 1
            4    15  16 2
            5    16   8 1
            6     4   6 1
            7    14  17 1
            8     7   8 1
            9     7   9 1
            10   17  18 2
            11   18  19 1
            12   19  20 2
            13   20  21 1
            14   21  22 2
            15   22  17 1
            16    1   2 1
            17   18  23 1
            18    2  10 1
            19   10  11 2
            20   11   9 1
            21   23  24 2
            22   24  25 1
            23   25  26 2
            24   26  27 1
            25   27  23 1
            26    9   6 1
            27    6   2 2
            28    1  28 1
            29    1   3 1
            30    1  29 1
            31    4  30 2
            32    4   5 1
            33   11  31 1
            34   31  32 1
            35    8  12 2
            36   32  33 1

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