KEGG   DRUG: D05277Help
Entry
D05277                      Drug                                   

Name
Formoterol fumarate hydrate (JP16);
Formoterol fumarate dihydrate;
Atock (TN);
Foradil (TN)
Product
Formula
(C19H24N2O4)2. C4H4O4. 2H2O
Exact mass
840.3793
Mol weight
840.9124
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Bronchodilator [DS:H00079]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Comment
Component of Symbicort (TN)
Long-acting beta-adrenoceptor agonist (LABA)
Target
beta2-adrenergic receptor agonist [HSA:154] [KO:K04142]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04144  Endocytosis
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: UGT [KO:K00699]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 R RESPIRATORY SYSTEM
  R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES
   R03A ADRENERGICS, INHALANTS
    R03AC Selective beta-2-adrenoreceptor agonists
     R03AC13 Formoterol
      D05277  Formoterol fumarate hydrate (JP16)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Bronchodilators, Sympathomimetic
   Formoterol
    D05277  Formoterol fumarate hydrate (JP16)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  22  Respiratory organ agents
   225  Bronchodilators
    2259  Others
     D05277  Formoterol fumarate hydrate (JP16)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta2-adrenergic receptor
     Formoterol
      D05277  Formoterol fumarate hydrate (JP16)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D05277  Formoterol fumarate hydrate
BRITE hierarchy
Other DBs
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        60
            1   O0  O    46.7600  -20.0900
            2   C6a C    38.0100  -20.8600
            3   C2b C    39.2000  -21.5600
            4   O6a O    36.7500  -21.5600
            5   O6a O    38.0100  -19.4600
            6   C2b C    40.3900  -20.8600
            7   C6a C    41.5800  -21.5600
            8   O6a O    42.8400  -20.8600
            9   O6a O    41.5800  -22.8900
            10  C8y C    20.0200  -21.5600
            11  C8x C    18.8300  -22.2600
            12  C8x C    20.0200  -20.1600
            13  C1c C    21.2100  -22.2600
            14  C8y C    17.5700  -21.5600
            15  C8x C    18.8300  -19.4600
            16  C1b C    22.4700  -21.5600
            17  O1a O    21.2100  -23.6600
            18  C8y C    17.5700  -20.1600
            19  N1b N    16.3800  -22.2600
            20  N1b N    23.6600  -22.2600
            21  O1a O    16.3800  -19.4600
            22  C4a C    15.1900  -21.5600
            23  C1c C    24.8500  -21.5600
            24  O4a O    13.9300  -22.2600
            25  C1b C    26.0400  -22.2600
            26  C1a C    24.8500  -20.1600
            27  C8y C    27.3000  -21.5600
            28  C8x C    27.3000  -20.1600
            29  C8x C    28.4900  -22.2600
            30  C8x C    28.4900  -19.4600
            31  C8x C    29.6800  -21.5600
            32  C8y C    29.6800  -20.1600
            33  O2a O    30.9400  -19.3900
            34  C1a C    32.1300  -20.0900
            35  O0  O    46.6900  -21.9100
            36  C8y C    20.0200  -21.5600
            37  C8x C    18.8300  -22.2600
            38  C8y C    17.5700  -21.5600
            39  C8y C    17.5700  -20.1600
            40  O1a O    16.3800  -19.4600
            41  C8x C    18.8300  -19.4600
            42  C8x C    20.0200  -20.1600
            43  N1b N    16.3800  -22.2600
            44  C4a C    15.1900  -21.5600
            45  O4a O    13.9300  -22.2600
            46  C1c C    21.2100  -22.2600
            47  C1b C    22.4700  -21.5600
            48  N1b N    23.6600  -22.2600
            49  C1c C    24.8500  -21.5600
            50  C1b C    26.0400  -22.2600
            51  C8y C    27.3000  -21.5600
            52  C8x C    27.3000  -20.1600
            53  C8x C    28.4900  -19.4600
            54  C8y C    29.6800  -20.1600
            55  O2a O    30.9400  -19.3900
            56  C1a C    32.1300  -20.0900
            57  C8x C    29.6800  -21.5600
            58  C8x C    28.4900  -22.2600
            59  C1a C    24.8500  -20.1600
            60  O1a O    21.2100  -23.6600
BOND        59
            1     2   3 1
            2     2   4 1
            3     2   5 2
            4     3   6 2
            5     6   7 1
            6     7   8 1
            7     7   9 2
            8    10  11 2
            9    10  12 1
            10   10  13 1
            11   11  14 1
            12   12  15 2
            13   13  16 1
            14   13  17 1
            15   14  18 2
            16   14  19 1
            17   16  20 1
            18   18  21 1
            19   19  22 1
            20   20  23 1
            21   22  24 2
            22   23  25 1
            23   23  26 1
            24   25  27 1
            25   27  28 2
            26   27  29 1
            27   28  30 1
            28   29  31 2
            29   30  32 2
            30   32  33 1
            31   33  34 1
            32   15  18 1
            33   31  32 1
            34   36  37 2
            35   36  42 1
            36   36  46 1
            37   37  38 1
            38   42  41 2
            39   46  47 1
            40   46  60 1
            41   38  39 2
            42   38  43 1
            43   47  48 1
            44   39  40 1
            45   43  44 1
            46   48  49 1
            47   44  45 2
            48   49  50 1
            49   49  59 1
            50   50  51 1
            51   51  52 2
            52   51  58 1
            53   52  53 1
            54   58  57 2
            55   53  54 2
            56   54  55 1
            57   55  56 1
            58   41  39 1
            59   57  54 1
BRACKET     1    12.7400  -24.3600   12.7400  -17.9900
            1    34.3000  -17.9900   34.3000  -24.3600
            1  2
 ORIGINAL  1   10  11  14  18  21  15  12  19  22  24  13  16  20  23  25  27
            1   28  30  32  33  34  31  29  26  17
 REPEAT    1   36  37  38  39  40  41  42  43  44  45  46  47  48  49  50  51
            1   52  53  54  55  56  57  58  59  60

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