| Entry |
|
|---|
| Name |
Paliperidone (JAN/USAN/INN);
Invega (TN)
|
|---|
| Product |
|
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| Formula |
C23H27FN4O3
|
|---|
| Exact mass |
426.2067
|
|---|
| Mol weight |
426.4839
|
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| Structure |
     |
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| Activity |
Treatment of schizophrenia
|
|---|
| Remark |
Therapeutic category: ATC code: |
|---|
| Comment |
Serotonin-dopamine antagonists (SDA)
|
|---|
| Target |
5-HT2A-receptor antagonist [HSA: 3356] [KO: K04157]; dopamine D2-receptor antagonist [HSA: 1813] [KO: K04145] |
|---|
| Pathway |
|
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| Interaction |
|
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
1 Agents affecting nervous system and sensory organs
11 Agents affecting central nervous system
117 Psychotropics
1179 Others
D05339 Paliperidone (JAN/USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
N NERVOUS SYSTEM
N05 PSYCHOLEPTICS
N05A ANTIPSYCHOTICS
N05AX Other antipsychotics
N05AX13 Paliperidone
D05339 Paliperidone (JAN/USAN/INN)
USP drug classification [BR:br08302]
Antipsychotics
2nd Generation/Atypical
Paliperidone
D05339 Paliperidone (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
G Protein-coupled receptors
Rhodopsin family
Dopamine
dopamine D2-receptor [HSA:1813] [KO:K04145]
Paliperidone [ATC:N05AX13]
D05339 Paliperidone (JAN/USAN/INN)
Serotonin
5-HT2A-receptor [HSA:3356] [KO:K04157]
Paliperidone [ATC:N05AX13]
D05339 Paliperidone (JAN/USAN/INN)
 |
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| Other DBs |
CAS: 144598-75-4 PubChem: DrugBank: LigandBox: NIKKAJI: |
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| KCF data |
ATOM 31
1 C8y C 28.1714 -16.6998
2 C8y C 28.1714 -15.3022
3 N5x N 26.9834 -14.6033
4 C8y C 25.7256 -15.3022
5 N4y N 25.7256 -16.6998
6 C8y C 26.9834 -17.3986
7 C1y C 24.5376 -14.6033
8 C1x C 23.3496 -15.3022
9 C1x C 23.3496 -16.6998
10 C1x C 24.5376 -17.3986
11 O1a O 24.5376 -13.2057
12 C1a C 29.3847 -14.6082
13 O5x O 26.9306 -18.7962
14 C1b C 29.3847 -17.3937
15 C1b C 30.5711 -16.7021
16 N1y N 31.7655 -17.3852
17 C1x C 31.7716 -18.7958
18 C1x C 32.9848 -19.4895
19 C1y C 34.1923 -18.7855
20 C1x C 34.1863 -17.3749
21 C1x C 32.9729 -16.6812
22 C8y C 35.4019 -19.4771
23 N5x N 35.3981 -20.8866
24 O2x O 36.7399 -21.3247
25 C8y C 37.5713 -20.1839
26 C8y C 36.7433 -19.0408
27 C8x C 38.9713 -20.1839
28 C8y C 39.6861 -18.9453
29 X F 41.0898 -18.9451
30 C8x C 38.9975 -17.7533
31 C8x C 37.5903 -17.7535
BOND 35
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 1
6 1 6 1
7 4 7 1
8 7 8 1
9 8 9 1
10 9 10 1
11 5 10 1
12 7 11 1 #Up
13 2 12 1
14 6 13 2
15 1 14 1
16 14 15 1
17 15 16 1
18 16 17 1
19 17 18 1
20 18 19 1
21 19 20 1
22 20 21 1
23 16 21 1
24 19 22 1
25 22 23 2
26 23 24 1
27 24 25 1
28 25 26 1
29 22 26 1
30 25 27 2
31 27 28 1
32 28 29 1
33 28 30 2
34 30 31 1
35 31 26 2
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