KEGG   DRUG: D05353Help
Entry
D05353                      Drug                                   

Name
Pantoprazole (USAN/INN)
Formula
C16H15F2N3O4S
Exact mass
383.0751
Mol weight
383.3698
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-ulcerative
Remark
Same as: 
ATC code: 
Drug group: 
Comment
proton pump inhibitor
Target
H+/K+ exchanging, alpha polypeptide inhibitor [HSA:495] [KO:K01542];
H+/K+ exchanging, beta polypeptide inhibitor [HSA:496] [KO:K01543]
  Pathway
hsa00190  Oxidative phosphorylation
hsa04966  Collecting duct acid secretion
hsa04971  Gastric acid secretion  
 
Metabolism
Enzyme: CYP2C19 [HSA:1557]
Interaction
Genomic biomarker: CYP2C19 [HSA:1557]
CYP inhibition: CYP2C19 [HSA:1557]
Drug interaction
Structure map
Antiulcer drugs
Ion transporter inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BC Proton pump inhibitors
     A02BC02 Pantoprazole
      D05353  Pantoprazole (USAN/INN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Proton Pump Inhibitors
   Pantoprazole
    D05353  Pantoprazole (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   H+/K+ exchanging, polypeptide
    Pantoprazole
     D05353  Pantoprazole (USAN/INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2C19
   Pantoprazole
    D05353  Pantoprazole (USAN/INN)
 Inhbitors
  CYP2C19
   Pantoprazole
    D05353  Pantoprazole (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
102625-70-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   C8x C    13.5800  -22.8200
            2   C8y C    13.5800  -24.2200
            3   C8x C    14.7924  -24.9200
            4   C8y C    16.0049  -24.2200
            5   C8y C    16.0049  -22.8200
            6   C8x C    14.7924  -22.1200
            7   N5x N    17.3364  -24.6526
            8   C8y C    18.1593  -23.5200
            9   N4x N    17.3364  -22.3874
            10  S4a S    19.5300  -23.5200
            11  C1b C    20.2300  -24.7324
            12  O3c O    20.2300  -22.3076
            13  O2a O    12.3676  -24.9200
            14  C1c C    11.1721  -24.2296
            15  X   F     9.9847  -24.9151
            16  X   F    11.1720  -22.8203
            17  C8y C    21.6298  -24.7324
            18  C8y C    22.3203  -25.9280
            19  C8y C    23.7203  -25.9278
            20  C8x C    24.4201  -24.7153
            21  C8x C    23.7297  -23.5198
            22  N5x N    22.3297  -23.5199
            23  O2a O    21.6349  -27.1152
            24  C1a C    20.2302  -27.1154
            25  O2a O    24.4110  -27.1232
            26  C1a C    25.8296  -27.1232
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    5   9 1
            11    8  10 1
            12   10  11 1
            13   10  12 2
            14    2  13 1
            15   13  14 1
            16   14  15 1
            17   14  16 1
            18   11  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22   20  21 1
            23   21  22 2
            24   17  22 1
            25   18  23 1
            26   23  24 1
            27   19  25 1
            28   25  26 1

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