KEGG   DRUG: D05380Help
Entry
D05380                      Drug                                   

Name
Pazopanib hydrochloride (JAN/USAN);
Votrient (TN)
Product
Formula
C21H23N7O2S. HCl
Exact mass
473.1401
Mol weight
473.979
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antineoplastic agent, a potent and selective inhibitor of VEGFR-1, -2 and -3 tyrosine kinases, blocking angiogenesis [DS:H00037 H00049 H00050 H00051 H00052 H00053]
Remark
Therapeutic category: 
ATC code: 
Target
PDGFRA tyrosine kinase inhibitor [HSA:5156] [KO:K04363];
PDGFRB tyrosine kinase inhibitor [HSA:5159] [KO:K05089];
VEGFR1 tyrosine kinase inhibitor [HSA:2321] [KO:K05096];
VEGFR2 tyrosine kinase inhibitor [HSA:3791] [KO:K05098];
VEGFR3 tyrosine kinase inhibitor [HSA:2324] [KO:K05097];
c-KIT tyrosine kinase inhibitor [HSA:3815] [KO:K05091]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa05200  Pathways in cancer  
 
Interaction
Genomic biomarker: UGT1A1 [HSA:54658]
CYP inhibition: CYP2D6 [HSA:1565], CYP3A [HSA:1576 1577 1551]
Drug interaction
Structure map
Antineoplastics - protein kinases inhibitors
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D05380  Pazopanib hydrochloride (JAN/USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XE Protein kinase inhibitors
     L01XE11 Pazopanib
      D05380  Pazopanib hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Pazopanib
    D05380  Pazopanib hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRA tyrosine kinase [HSA:5156] [KO:K04363]
     Pazopanib [ATC:L01XE11]
      D05380  Pazopanib hydrochloride (JAN/USAN)
    PDGFRB tyrosine kinase [HSA:5159] [KO:K05089]
     Pazopanib [ATC:L01XE11]
      D05380  Pazopanib hydrochloride (JAN/USAN)
    c-KIT tyrosine kinase [HSA:3815] [KO:K05091]
     Pazopanib [ATC:L01XE11]
      D05380  Pazopanib hydrochloride (JAN/USAN)
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase [HSA:2321] [KO:K05096]
     Pazopanib [ATC:L01XE11]
      D05380  Pazopanib hydrochloride (JAN/USAN)
    VEGFR2 tyrosine kinase [HSA:3791] [KO:K05098]
     Pazopanib [ATC:L01XE11]
      D05380  Pazopanib hydrochloride (JAN/USAN)
    VEGFR3 tyrosine kinase [HSA:2324] [KO:K05097]
     Pazopanib [ATC:L01XE11]
      D05380  Pazopanib hydrochloride (JAN/USAN)
Antineoplastics [BR:br08308]
 Molecularly targeted agents
  Receptor tyrosine kinase inhibitors
   Pazopanib [ATC:L01XE11]
    D05380  Pazopanib hydrochloride (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
635702-64-6
PubChem: 
LigandBox: 
KCF data Show

ATOM        32
            1   C8x C     8.1900  -18.2000
            2   C8y C     8.1900  -19.6000
            3   C8y C     9.4024  -20.3000
            4   C8x C    10.6149  -19.6000
            5   C8y C    10.6149  -18.2000
            6   C8x C     9.4024  -17.5000
            7   N5x N    13.0397  -19.6000
            8   C8y C    13.0397  -18.2000
            9   N1b N    11.8273  -17.5000
            10  C8x C    14.2522  -20.3000
            11  C8x C    15.4646  -19.6000
            12  C8y C    15.4646  -18.2000
            13  N5x N    14.2522  -17.5000
            14  N1c N    16.6811  -17.4977
            15  C8y C    17.8786  -18.1892
            16  C1a C    16.6811  -16.1002
            17  C1a C     6.9776  -20.3000
            18  S4a S     9.4024  -21.6998
            19  N1a N     9.4024  -23.0998
            20  O3c O     7.9800  -21.6998
            21  O3c O    10.7800  -21.6998
            22  C8x C    17.8787  -19.5997
            23  C8x C    19.0911  -20.2996
            24  C8y C    20.3035  -19.5996
            25  C8y C    20.3035  -18.1891
            26  C8x C    19.0910  -17.4892
            27  C8y C    21.6450  -20.0354
            28  N4y N    22.4741  -18.8942
            29  N5x N    21.6449  -17.7532
            30  C1a C    23.8700  -18.8942
            31  C1a C    22.0716  -21.3485
            32  X   Cl   22.1900  -23.9400
BOND        34
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 2
            11   10  11 1
            12   11  12 2
            13   12  13 1
            14    8  13 2
            15   12  14 1
            16   14  15 1
            17   14  16 1
            18    2  17 1
            19    3  18 1
            20   18  19 1
            21   18  20 2
            22   18  21 2
            23   15  22 1
            24   22  23 2
            25   23  24 1
            26   24  25 1
            27   25  26 1
            28   15  26 2
            29   24  27 2
            30   27  28 1
            31   28  29 1
            32   25  29 2
            33   28  30 1
            34   27  31 1

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