| Entry |
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| Name |
Pazopanib hydrochloride (JAN/USAN);
Votrient (TN)
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| Product |
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| Formula |
C21H23N7O2S. HCl
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| Exact mass |
473.1401
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| Mol weight |
473.979
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| Structure |
     |
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| Activity |
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| Remark |
Therapeutic category: ATC code: |
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| Target |
PDGFRA tyrosine kinase inhibitor [HSA: 5156] [KO: K04363]; PDGFRB tyrosine kinase inhibitor [HSA: 5159] [KO: K05089]; VEGFR1 tyrosine kinase inhibitor [HSA: 2321] [KO: K05096]; VEGFR2 tyrosine kinase inhibitor [HSA: 3791] [KO: K05098]; VEGFR3 tyrosine kinase inhibitor [HSA: 2324] [KO: K05097]; c-KIT tyrosine kinase inhibitor [HSA: 3815] [KO: K05091] |
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| Pathway |
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| Interaction |
CYP inhibition: CYP2D6 [HSA: 1565], CYP3A [KO: K07424]
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| Structure map |
| Antineoplastics - protein kinases inhibitors |
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| Brite |
Therapeutic category of drugs in Japan [BR:br08301]
4 Agents affecting cellular function
42 Antineoplastics
429 Miscellaneous
4291 Other Antitumors
D05380 Pazopanib hydrochloride (JAN/USAN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 ANTINEOPLASTIC AGENTS
L01X OTHER ANTINEOPLASTIC AGENTS
L01XE Protein kinase inhibitors
L01XE11 Pazopanib
D05380 Pazopanib hydrochloride (JAN/USAN)
USP drug classification [BR:br08302]
Antineoplastics
Molecular Target Inhibitors
Multitargeted Kinase Inhibitors, Vascular Endothelial Growth Factor Receptor Tyrosine Kinase Inhibitors
Pazopanib
D05380 Pazopanib hydrochloride (JAN/USAN)
Target-based classification of drugs [BR:br08310]
Cytokine receptors
Receptor tyrosine kinase
RTK class III (PDGF receptor family)
PDGFRA tyrosine kinase [HSA:5156] [KO:K04363]
Pazopanib [ATC:L01XE11]
D05380 Pazopanib hydrochloride (JAN/USAN)
PDGFRB tyrosine kinase [HSA:5159] [KO:K05089]
Pazopanib [ATC:L01XE11]
D05380 Pazopanib hydrochloride (JAN/USAN)
c-KIT tyrosine kinase [HSA:3815] [KO:K05091]
Pazopanib [ATC:L01XE11]
D05380 Pazopanib hydrochloride (JAN/USAN)
RTK class V (VEGF receptor family)
VEGFR1 tyrosine kinase [HSA:2321] [KO:K05096]
Pazopanib [ATC:L01XE11]
D05380 Pazopanib hydrochloride (JAN/USAN)
VEGFR2 tyrosine kinase [HSA:3791] [KO:K05098]
Pazopanib [ATC:L01XE11]
D05380 Pazopanib hydrochloride (JAN/USAN)
VEGFR3 tyrosine kinase [HSA:2324] [KO:K05097]
Pazopanib [ATC:L01XE11]
D05380 Pazopanib hydrochloride (JAN/USAN)
Antineoplastics [BR:br08308]
Molecularly targeted agents
Receptor tyrosine kinase inhibitors
Pazopanib [ATC:L01XE11]
D05380 Pazopanib hydrochloride (JAN/USAN)
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| Other DBs |
CAS: 635702-64-6 PubChem: LigandBox: |
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| KCF data |
ATOM 32
1 C8x C 8.1900 -18.2000
2 C8y C 8.1900 -19.6000
3 C8y C 9.4024 -20.3000
4 C8x C 10.6149 -19.6000
5 C8y C 10.6149 -18.2000
6 C8x C 9.4024 -17.5000
7 N5x N 13.0397 -19.6000
8 C8y C 13.0397 -18.2000
9 N1b N 11.8273 -17.5000
10 C8x C 14.2522 -20.3000
11 C8x C 15.4646 -19.6000
12 C8y C 15.4646 -18.2000
13 N5x N 14.2522 -17.5000
14 N1c N 16.6811 -17.4977
15 C8y C 17.8786 -18.1892
16 C1a C 16.6811 -16.1002
17 C1a C 6.9776 -20.3000
18 S4a S 9.4024 -21.6998
19 N1a N 9.4024 -23.0998
20 O3c O 7.9800 -21.6998
21 O3c O 10.7800 -21.6998
22 C8x C 17.8787 -19.5997
23 C8x C 19.0911 -20.2996
24 C8y C 20.3035 -19.5996
25 C8y C 20.3035 -18.1891
26 C8x C 19.0910 -17.4892
27 C8y C 21.6450 -20.0354
28 N4y N 22.4741 -18.8942
29 N5x N 21.6449 -17.7532
30 C1a C 23.8700 -18.8942
31 C1a C 22.0716 -21.3485
32 X Cl 22.1900 -23.9400
BOND 34
1 1 2 2
2 2 3 1
3 3 4 2
4 4 5 1
5 5 6 2
6 1 6 1
7 7 8 1
8 8 9 1
9 5 9 1
10 7 10 2
11 10 11 1
12 11 12 2
13 12 13 1
14 8 13 2
15 12 14 1
16 14 15 1
17 14 16 1
18 2 17 1
19 3 18 1
20 18 19 1
21 18 20 2
22 18 21 2
23 15 22 1
24 22 23 2
25 23 24 1
26 24 25 1
27 25 26 1
28 15 26 2
29 24 27 2
30 27 28 1
31 28 29 1
32 25 29 2
33 28 30 1
34 27 31 1
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