KEGG   DRUG: D05386Help
Entry
D05386                      Drug                                   

Name
Pegaptanib sodium (JAN/USAN);
Macugen (TN)
Product
Formula
C294H342F13N107O188P28(C2H4O)n. 28Na
Activity
Treatment of age-related macular degeneration disease [anti-VEGF aptamer] [DS:H00821]
Remark
Therapeutic category: 
ATC code: 
Comment
Pegaptanib inhibits VEGF165 selectively.
angiogenesis inhibitor
Target
anti-VEGFA aptamer [HSA:7422] [KO:K05448]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer  
 
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01L OCULAR VASCULAR DISORDER AGENTS
    S01LA Antineovascularisation agents
     S01LA03 Pegaptanib
      D05386  Pegaptanib sodium (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D05386  Pegaptanib sodium (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Cytokines
  PDGF family
   VEGFA
    Pegaptanib
     D05386  Pegaptanib sodium (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
222716-86-1
PubChem: 
NIKKAJI: 

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