KEGG   DRUG: D05393Help
Entry
D05393                      Drug                                   
Name
Pegsunercept (USAN)
Formula
C502H758N154O165S16
Exact mass
12095.1188
Mol weight
12103.3627
Sequence
MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC
LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFN
(Disulfide bridge: 5-19; 20-33; 23-42; 63-78; 66-86: 88-104)
  Type
Peptide
Activity
Treatment of inflammatory and autoimmune conditions (e.g. rheumatoid arthritis, Crohn's disease) [binds and therapy inhibits the inflammatory activity of tumor necrosis factor]
Comment
a PEGylated protein (a polyethylene-glycol-modified soluble tumor-necrosis-factor receptor type 1)
Target
TNF-alpha [HSA:7124] [KO:K03156]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04064  NF-kappa B signaling pathway
hsa04150  mTOR signaling pathway
hsa04350  TGF-beta signaling pathway
hsa05323  Rheumatoid arthritis  
 
Brite
Target-based classification of drugs [BR:br08310]
 Cytokines
  TNF family
   TNF-alpha [HSA:7124] [KO:K03156]
    Pegsunercept
     D05393  Pegsunercept (USAN)
BRITE hierarchy
Other DBs
CAS: 
330988-75-5
PubChem: 

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