KEGG   DRUG: PegvisomantHelp
Entry
D05394                      Drug                                   

Name
Pegvisomant (USAN/INN);
Pegvisomant (genetical recombination) (JAN);
Somavent (TN)
Product
Sequence
FPTIPLSRLF DNAMLRADRL NQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT
PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS LVYGASDSNV YDLLKDLEEK
IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFNADM SRVSTFLRTV
QCRSVEGSCG F
  Type
Peptide
Remark
Therapeutic category: 
ATC code: 
Activity
Growth hormone receptor antagonist
Comment
Treatment of acromegaly (competitive inhibition of peripheral growth hormone receptors to block IFG-I production)
Target
GHR [HSA:2690] [KO:K05080]
  Pathway
Cytokine-cytokine receptor interaction
Neuroactive ligand-receptor interaction
Jak-STAT signaling pathway
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
   H01A ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES
    H01AX Other anterior pituitary lobe hormones and analogues
     H01AX01 Pegvisomant
      D05394  Pegvisomant (USAN/INN)
USP drug classification [BR:br08302]
 Hormonal Agents, Suppressant (Pituitary)
  Pegvisomant
   D05394  Pegvisomant (USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D05394  Pegvisomant (USAN/INN); Pegvisomant (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class I cytokine receptors (hematopoietin family receptors)
   growth hormone receptor
    Pegvisomant
     D05394  Pegvisomant (USAN/INN)
Endocrine and hormonal agents [br08373.html]
 Hormone related agents
  D05394
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D05394
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D05394
BRITE hierarchy
Other DBs
CAS: 
218620-50-9
PubChem: 
DrugBank: 
NIKKAJI: 

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