KEGG   DRUG: D05394Help
Entry
D05394                      Drug                                   

Name
Pegvisomant (genetical recombination) (JAN);
Pegvisomant (USAN/INN);
Somavent (TN)
Product
Sequence
FPTIPLSRLF DNAMLRADRL NQLAFDTYQE FEEAYIPKEQ KYSFLQNPQT SLCFSESIPT
PSNREETQQK SNLELLRISL LLIQSWLEPV QFLRSVFANS LVYGASDSNV YDLLKDLEEK
IQTLMGRLED GSPRTGQIFK QTYSKFDTNS HNDDALLKNY GLLYCFNADM SRVSTFLRTV
QCRSVEGSCG F
  Type
Peptide
Activity
Treatment of acromegaly [competitive inhibition of peripheral growth hormone receptors to block IFG-I production]
Remark
Therapeutic category: 
ATC code: 
Target
growth hormone receptor antagonist [HSA:2690] [KO:K05080]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04080  Neuroactive ligand-receptor interaction
hsa04630  Jak-STAT signaling pathway  
 
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  24  Hormones
   249  Miscellaneous
    2499  Others
     D05394  Pegvisomant (genetical recombination) (JAN); Pegvisomant (USAN/INN)
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 H SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
  H01 PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
   H01A ANTERIOR PITUITARY LOBE HORMONES AND ANALOGUES
    H01AX Other anterior pituitary lobe hormones and analogues
     H01AX01 Pegvisomant
      D05394  Pegvisomant (genetical recombination) (JAN); Pegvisomant (USAN/INN)
USP drug classification [BR:br08302]
 Hormonal Agents, Suppressant (Pituitary)
  Pegvisomant
   D05394  Pegvisomant (genetical recombination) (JAN); Pegvisomant (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class I cytokine receptors (hematopoietin family receptors)
   growth hormone receptor [HSA:2690] [KO:K05080]
    Pegvisomant [ATC:H01AX01]
     D05394  Pegvisomant (genetical recombination) (JAN); Pegvisomant (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
218620-50-9
PubChem: 
DrugBank: 
NIKKAJI: 

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