KEGG   DRUG: D05442Help
Entry
D05442                      Drug                                   

Name
Perhexiline maleate (USAN)
Formula
C19H35N. C4H4O4
Exact mass
393.2879
Mol weight
393.5601
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Vasodilator [coronary], Coronary vasodilator, Calcium antagonist
Remark
ATC code: 
Drug group: 
Target
L-type calcium channel blocker [HSA:775 776 778 779] [KO:K04850 K04851 K04853 K04857];
carnitine palmitoyltransferase (CPT) inhibitor [HSA:1374 1375 126129 1376] [KO:K08765 K08766]
  Pathway
hsa04020  Calcium signaling pathway
hsa04260  Cardiac muscle contraction  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C08 CALCIUM CHANNEL BLOCKERS
   C08E NON-SELECTIVE CALCIUM CHANNEL BLOCKERS
    C08EX Other non-selective calcium channel blockers
     C08EX02 Perhexiline
      D05442  Perhexiline maleate (USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Ca2+ channel, CACN alpha-1, CaVx.x
    calcium channel L type
     Perhexiline
      D05442  Perhexiline maleate (USAN)
 Enzymes
  Transferases
   carnitine palmitoyltransferase (CPT) 1
    Perhexiline
     D05442  Perhexiline maleate (USAN)
   carnitine palmitoyltransferase (CPT) 2
    Perhexiline
     D05442  Perhexiline maleate (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Perhexiline
    D05442  Perhexiline maleate (USAN)
BRITE hierarchy
Other DBs
CAS: 
6724-53-4
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C1x C     8.2600  -21.2800
            2   C1x C     8.2600  -22.6800
            3   C1x C     9.4724  -23.3800
            4   C1x C    10.6849  -22.6800
            5   C1y C    10.6849  -21.2800
            6   C1x C     9.4724  -20.5800
            7   C1x C    13.1097  -22.6800
            8   C1y C    13.1097  -21.2800
            9   C1c C    11.8973  -20.5800
            10  C1x C    14.3222  -23.3800
            11  C1x C    15.5346  -22.6800
            12  C1x C    15.5346  -21.2800
            13  C1x C    14.3222  -20.5800
            14  C1b C    11.8973  -19.1800
            15  C1y C    13.1118  -18.4788
            16  N1x N    14.3083  -19.1698
            17  C1x C    15.5208  -18.4699
            18  C1x C    15.5209  -17.0699
            19  C1x C    14.3244  -16.3790
            20  C1x C    13.1119  -17.0788
            21  C2b C    21.5984  -19.0046
            22  C2b C    19.7886  -19.0046
            23  C6a C    19.1621  -20.1879
            24  C6a C    22.2945  -20.1879
            25  O6a O    19.7886  -21.3713
            26  O6a O    21.5984  -21.3713
            27  O6a O    23.6866  -20.1879
            28  O6a O    17.8395  -20.1879
BOND        29
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     5   9 1
            10    7  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14    8  13 1
            15    9  14 1
            16   14  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   15  20 1
            23   21  22 2
            24   22  23 1
            25   21  24 1
            26   23  25 2
            27   24  26 1
            28   24  27 2
            29   23  28 1

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