KEGG   DRUG: D05461Help
Entry
D05461                      Drug                                   

Name
Enoxacin hydrate (JP16)
Formula
(C15H17FN4O3)3. 2H2O
Exact mass
996.4065
Mol weight
996.9872
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
ATC code: 
Drug group: 
Target
DNA gyrase inhibitor [KO:K02469 K02470];
topoisomerase IV inhibitor [KO:K02621 K02622]
Metabolism
Enzyme: CYP1A2 [HSA:1544]
Interaction
CYP inhibition: CYP1A2 [HSA:1544]
Drug interaction
Structure map
Quinolones
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01M QUINOLONE ANTIBACTERIALS
    J01MA Fluoroquinolones
     J01MA04 Enoxacin
      D05461  Enoxacin hydrate (JP16)
Antiinfectives [BR:br08307]
 Antibacterials
  Nucleic acid synthesis inhibitor
   type II topoisomerase (DNA gyrase, topoisomerase IV) inhibitor
    Fluoroquinolones
     Enoxacin
      D05461  Enoxacin hydrate (JP16)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Enoxacin
    D05461  Enoxacin hydrate (JP16)
  CYP3A4
   Enoxacin
    D05461  Enoxacin hydrate (JP16)
 Inhbitors
  CYP1A2
   Enoxacin
    D05461  Enoxacin hydrate (JP16)
   Enoxacin
    D05461  Enoxacin hydrate (JP16)
Drugs listed in the Japanese Pharmacopoeia [BR:br08311]
 Chemicals
  D05461  Enoxacin hydrate
BRITE hierarchy
Other DBs
CAS: 
84294-96-2
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        71
            1   C8y C    30.8700  -15.8200
            2   C8y C    30.8700  -14.4200
            3   N4y N    32.0600  -16.5200
            4   N5x N    29.6800  -16.5200
            5   C8y C    32.1300  -13.7200
            6   C8x C    29.6800  -13.7200
            7   C8x C    33.3200  -15.8200
            8   C1b C    32.0600  -17.9200
            9   C8y C    28.4900  -15.8200
            10  C8y C    33.3200  -14.4200
            11  O5x O    32.1300  -12.3200
            12  C8y C    28.4900  -14.4200
            13  C1a C    30.8700  -18.6200
            14  N1y N    27.2300  -16.5200
            15  C6a C    34.5100  -13.7200
            16  X   F    27.2300  -13.7200
            17  C1x C    27.2300  -17.9200
            18  C1x C    26.0400  -15.8200
            19  O6a O    35.7700  -14.4200
            20  O6a O    34.5100  -12.3200
            21  C1x C    26.0400  -18.6200
            22  C1x C    24.8500  -16.5200
            23  N1x N    24.8500  -17.9200
            24  O0  O    40.1100  -15.5400
            25  C8y C    30.8700  -15.8200
            26  C8y C    30.8700  -14.4200
            27  C8y C    32.1300  -13.7200
            28  C8y C    33.3200  -14.4200
            29  C6a C    34.5100  -13.7200
            30  O6a O    35.7700  -14.4200
            31  O6a O    34.5100  -12.3200
            32  C8x C    33.3200  -15.8200
            33  N4y N    32.0600  -16.5200
            34  C1b C    32.0600  -17.9200
            35  C1a C    30.8700  -18.6200
            36  O5x O    32.1300  -12.3200
            37  C8x C    29.6800  -13.7200
            38  C8y C    28.4900  -14.4200
            39  X   F    27.2300  -13.7200
            40  C8y C    28.4900  -15.8200
            41  N5x N    29.6800  -16.5200
            42  N1y N    27.2300  -16.5200
            43  C1x C    27.2300  -17.9200
            44  C1x C    26.0400  -18.6200
            45  N1x N    24.8500  -17.9200
            46  C1x C    24.8500  -16.5200
            47  C1x C    26.0400  -15.8200
            48  C8y C    30.8700  -15.8200
            49  C8y C    30.8700  -14.4200
            50  C8y C    32.1300  -13.7200
            51  C8y C    33.3200  -14.4200
            52  C6a C    34.5100  -13.7200
            53  O6a O    35.7700  -14.4200
            54  O6a O    34.5100  -12.3200
            55  C8x C    33.3200  -15.8200
            56  N4y N    32.0600  -16.5200
            57  C1b C    32.0600  -17.9200
            58  C1a C    30.8700  -18.6200
            59  O5x O    32.1300  -12.3200
            60  C8x C    29.6800  -13.7200
            61  C8y C    28.4900  -14.4200
            62  X   F    27.2300  -13.7200
            63  C8y C    28.4900  -15.8200
            64  N5x N    29.6800  -16.5200
            65  N1y N    27.2300  -16.5200
            66  C1x C    27.2300  -17.9200
            67  C1x C    26.0400  -18.6200
            68  N1x N    24.8500  -17.9200
            69  C1x C    24.8500  -16.5200
            70  C1x C    26.0400  -15.8200
            71  O0  O    40.1100  -15.5400
BOND        75
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 1
            8     4   9 2
            9     5  10 1
            10    5  11 2
            11    6  12 2
            12    8  13 1
            13    9  14 1
            14   10  15 1
            15   12  16 1
            16   14  17 1
            17   14  18 1
            18   15  19 1
            19   15  20 2
            20   17  21 1
            21   18  22 1
            22   21  23 1
            23    7  10 2
            24    9  12 1
            25   22  23 1
            26   25  26 2
            27   25  33 1
            28   25  41 1
            29   26  27 1
            30   26  37 1
            31   33  32 1
            32   33  34 1
            33   41  40 2
            34   27  28 1
            35   27  36 2
            36   37  38 2
            37   34  35 1
            38   40  42 1
            39   28  29 1
            40   38  39 1
            41   42  43 1
            42   42  47 1
            43   29  30 1
            44   29  31 2
            45   43  44 1
            46   47  46 1
            47   44  45 1
            48   32  28 2
            49   40  38 1
            50   46  45 1
            51   48  49 2
            52   48  56 1
            53   48  64 1
            54   49  50 1
            55   49  60 1
            56   56  55 1
            57   56  57 1
            58   64  63 2
            59   50  51 1
            60   50  59 2
            61   60  61 2
            62   57  58 1
            63   63  65 1
            64   51  52 1
            65   61  62 1
            66   65  66 1
            67   65  70 1
            68   52  53 1
            69   52  54 2
            70   66  67 1
            71   70  69 1
            72   67  68 1
            73   55  51 2
            74   63  61 1
            75   69  68 1
BRACKET     1    23.3100  -19.3900   23.3100  -11.8300
            1    37.1000  -11.8300   37.1000  -19.3900
            1  3
 ORIGINAL  1    1   2   5  10  15  19  20   7   3   8  13  11   6  12  16   9
            1    4  14  17  21  23  22  18
 REPEAT    1   25  26  27  28  29  30  31  32  33  34  35  36  37  38  39  40
            1   41  42  43  44  45  46  47  48  49  50  51  52  53  54  55  56
            1   57  58  59  60  61  62  63  64  65  66  67  68  69  70
            2    38.1500  -16.3800   38.1500  -14.7000
            2    40.6000  -14.7000   40.6000  -16.3800
            2  2
 ORIGINAL  2   24
 REPEAT    2   71

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