KEGG   DRUG: D05523Help
Entry
D05523                      Drug                                   

Name
Pizotyline (USAN);
Pizotifen (INN);
Sandomigran (TN)
Formula
C19H21NS
Exact mass
295.1395
Mol weight
295.4417
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anabolic;
Antidepressant;
Serotonin inhibitor [specific in migraine]
Remark
ATC code: 
Drug group: 
Target
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157];
5-HT2C-receptor antagonist [HSA:3358] [KO:K04157];
5-HT1-receptor antagonist [HSA:3350 3351 3352 3354 3355] [KO:K04153]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02C ANTIMIGRAINE PREPARATIONS
    N02CX Other antimigraine preparations
     N02CX01 Pizotifen
      D05523  Pizotyline (USAN); Pizotifen (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT1-receptor
     Pizotifen
      D05523  Pizotyline (USAN); Pizotifen (INN)
    5-HT2A-receptor
     Pizotifen
      D05523  Pizotyline (USAN); Pizotifen (INN)
    5-HT2C-receptor
     Pizotifen
      D05523  Pizotyline (USAN); Pizotifen (INN)
BRITE hierarchy
Other DBs
CAS: 
15574-96-6
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        21
            1   C1x C    43.7952  -19.7173
            2   C8y C    42.9508  -18.6047
            3   C8y C    43.2869  -17.2442
            4   C2y C    44.5514  -16.6645
            5   C1x C    45.2048  -19.7426
            6   C8y C    45.8083  -17.2885
            7   C8y C    46.0956  -18.6610
            8   C8x C    42.2770  -16.2731
            9   C8x C    40.9314  -16.6623
            10  C8x C    40.5953  -18.0228
            11  C8x C    41.6051  -18.9936
            12  S2x S    47.4898  -18.6718
            13  C8x C    48.0641  -17.5326
            14  C8x C    47.0249  -16.5911
            15  C2y C    44.5514  -15.2645
            16  C1x C    45.7419  -14.5767
            17  C1x C    45.7416  -13.1767
            18  N1y N    44.5290  -12.4770
            19  C1x C    43.3385  -13.1648
            20  C1x C    43.3388  -14.5648
            21  C1a C    44.5287  -11.0600
BOND        24
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 2
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 1
            14   12  13 1
            15   13  14 2
            16    6  14 1
            17    4  15 2
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   15  20 1
            24   18  21 1

» Japanese version   » Back

DBGET integrated database retrieval system