KEGG   DRUG: Proinsulin humanHelp
Entry
D05622                      Drug                                   

Name
Proinsulin human (USAN)
Formula
C410H638N114O127S6
Exact mass
9382.5294
Mol weight
9388.5303
Sequence
FVNQHLCGSH LVEALYLVCG ERGFFYTPKT RREAEDLQVG QVELGGGPGA GSLQPLALEG
SLQKRGIVEQ CCTSICSLYQ LENYCN
(Disulfide bridge: 7-72; 19-85; 71-76)
  Type
Peptide
Class
Antidiabetic agent
 DG01636  Insulin and analogue
  DG01802  Human insulin
   DG01800  Human insulin, long-acting
Cyp inducer
 DG01637  CYP1A2 inducer
Activity
Antidiabetic, Insulin receptor agonist
Target
INSR (CD220) [HSA:3643] [KO:K04527]
  Pathway
Adherens junction
Insulin signaling pathway
Type II diabetes mellitus
Aldosterone-regulated sodium reabsorption
Interaction
CYP induction: CYP1A2 [HSA:1544]
Drug interaction
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class II (Insulin receptor family)
    insulin receptor
     Insulin (human)
      D05622  Proinsulin human (USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP inducers
  CYP1A2
   Insulin
    D05622  Proinsulin human (USAN)
BRITE hierarchy
Other DBs
CAS: 
67422-14-4
PubChem: 

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