KEGG   DRUG: D05660Help
Entry
D05660                      Drug                                   

Name
Pyrilamine maleate (USP);
Pymafed (TN)
Formula
C17H23N3O. C4H4O4
Exact mass
401.1951
Mol weight
401.4562
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihistaminic
Remark
ATC code: 
Comment
Pyrilamine is called Mepyramine in INN.
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA02 Mepyramine
      D05660  Pyrilamine maleate (USP)
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AC Substituted ethylene diamines
     R06AC01 Mepyramine
      D05660  Pyrilamine maleate (USP)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor [HSA:3269] [KO:K04149]
     Mepyramine [ATC:D04AA02 R06AC01]
      D05660  Pyrilamine maleate (USP)
BRITE hierarchy
Other DBs
CAS: 
59-33-6
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        29
            1   C8x C     4.1570   -4.4301
            2   C8y C     4.1570   -5.8320
            3   C8x C     5.3709   -6.5329
            4   C8x C     6.5851   -5.8320
            5   C8y C     6.5851   -4.4301
            6   C8x C     5.3709   -3.7292
            7   O2a O     2.9430   -6.5329
            8   C1a C     1.7459   -5.8416
            9   C1b C     7.8177   -3.7182
            10  N1c N     9.0246   -4.4148
            11  C1b C    10.2084   -3.7311
            12  C1b C    11.4040   -4.4213
            13  C8y C     9.0250   -5.8316
            14  N5x N     7.7875   -6.5469
            15  C8x C     7.7882   -7.9488
            16  C8x C     9.0026   -8.6490
            17  C8x C    10.2401   -7.9337
            18  C8x C    10.2393   -6.5318
            19  N1c N    12.5934   -3.7344
            20  C1a C    13.7861   -4.4230
            21  C1a C    12.5935   -2.3276
            22  C6a C    21.0885   -6.1462
            23  C2b C    20.4134   -4.9815
            24  O6a O    20.4889   -7.3864
            25  O6a O    22.4391   -6.1399
            26  C2b C    18.7965   -4.9877
            27  C6a C    18.1275   -6.1585
            28  O6a O    16.7769   -6.1585
            29  O6a O    18.8090   -7.3925
BOND        29
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     2   7 1
            8     7   8 1
            9     5   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   10  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   16  17 1
            18   17  18 2
            19   13  18 1
            20   12  19 1
            21   19  20 1
            22   19  21 1
            23   22  23 1
            24   22  24 1
            25   22  25 2
            26   23  26 2
            27   26  27 1
            28   27  28 1
            29   27  29 2

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