KEGG   DRUG: D05699Help
Entry
D05699                      Drug                                   

Name
Ranitidine bismuth citrate (USAN);
Tritec (TN)
Formula
C13H22N4O3S. Bi. C6H5O7
Exact mass
712.1252
Mol weight
712.4839
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antagonist [to histamine H2 receptors]
Remark
ATC code: 
Target
H2-receptor antagonist [HSA:3274] [KO:K04150]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04971  Gastric acid secretion  
 
Metabolism
Transporter: SLC22A2 [HSA:6582]
Interaction
CYP inhibition: CYP2D6 [HSA:1565], CYP3A [HSA:1576 1577 1551]
Transporter inhibition: SLC22A2 [HSA:6582]
Drug interaction
Structure map
Antiulcer drugs
Histamine H2/H3 receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BA H2-receptor antagonists
     A02BA07 Ranitidine bismuth citrate
      D05699  Ranitidine bismuth citrate (USAN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Histamine2 (H2) receptor Antagonists
   Ranitidine
    D05699  Ranitidine bismuth citrate (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H2-receptor
     Ranitidine bismuth citrate
      D05699  Ranitidine bismuth citrate (USAN)
Cytochrome P450 interactions [BR:br08309]
 Inhbitors
  CYP2D6
   Ranitidine bismuth citrate
    D05699  Ranitidine bismuth citrate (USAN)
BRITE hierarchy
Other DBs
CAS: 
128345-62-0
PubChem: 
LigandBox: 
KCF data Show

ATOM        35
            1   C8y C    19.0764  -19.5690
            2   O2x O    20.1947  -20.4079
            3   C8x C    19.4958  -18.2410
            4   C1b C    17.8181  -20.2680
            5   C8y C    21.3131  -19.5690
            6   C8x C    20.8937  -18.2410
            7   N1c N    16.6297  -19.5690
            8   C1b C    22.5015  -20.2680
            9   C1a C    15.4415  -20.2680
            10  C1a C    16.6297  -18.1711
            11  S2a S    23.6898  -19.5690
            12  C1b C    24.9479  -20.2680
            13  C1b C    26.1363  -19.5690
            14  N1b N    27.3246  -20.2680
            15  C2c C    28.5828  -19.5690
            16  C2b C    29.7711  -20.2680
            17  N1b N    28.5828  -18.1711
            18  N2b N    30.9595  -19.5690 #+
            19  C1a C    27.3246  -17.4721
            20  O3a O    30.9595  -18.1711 #-
            21  O3a O    32.2177  -20.2680
            22  C1d C    29.4061  -24.8142
            23  C1b C    28.1950  -25.5105
            24  C1b C    30.6174  -25.5045
            25  C6a C    30.0966  -23.5970
            26  O1a O    28.6981  -23.5970
            27  C6a C    26.9895  -24.8200
            28  C6a C    30.6057  -26.9032
            29  O6a O    29.3885  -22.3801 #-
            30  O6a O    31.5010  -23.5970
            31  O6a O    25.7784  -25.5222 #-
            32  O6a O    27.0478  -23.4217
            33  O6a O    31.8170  -27.6053 #-
            34  O6a O    29.3885  -27.5994
            35  Z   Bi   22.4698  -25.4097 #3+
BOND        33
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     7   9 1
            9     7  10 1
            10    8  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   14  15 1
            15   15  16 2
            16   15  17 1
            17   16  18 1
            18   17  19 1
            19   18  20 1
            20   18  21 2
            21    5   6 2
            22   22  23 1
            23   22  24 1
            24   22  25 1
            25   22  26 1
            26   23  27 1
            27   24  28 1
            28   25  29 1
            29   25  30 2
            30   27  31 1
            31   27  32 2
            32   28  33 1
            33   28  34 2

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