KEGG   DRUG: Ranitidine bismuth citrateHelp
Entry
D05699                      Drug                                   

Name
Ranitidine bismuth citrate (USAN);
Tritec (TN)
Formula
C13H22N4O3S. Bi. C6H5O7
Exact mass
712.1252
Mol weight
712.4839
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Gastrointestinal agent
 DG01481  Histamine receptor H2 antagonist
 DG01975  Agents for peptic ulcer
  DG01481  Histamine receptor H2 antagonist
Cyp inhibitor
 DG01645  CYP2D6 inhibitor
 DG01522  CYP3A4 inhibitor
Remark
ATC code: 
Activity
Anti-ulcerative, H2 receptor antagonist
Target
HRH2 [HSA:3274] [KO:K04150]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gastric acid secretion
Metabolism
Transporter: SLC22A2 [HSA:6582]
Interaction
CYP inhibition: CYP2D6 [HSA:1565], CYP3A [HSA:1576 1577 1551]
Transporter inhibition: SLC22A2 [HSA:6582]
Drug interaction
Structure map
Antiulcer drugs
Histamine H2/H3 receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A02 DRUGS FOR ACID RELATED DISORDERS
   A02B DRUGS FOR PEPTIC ULCER AND GASTRO-OESOPHAGEAL REFLUX DISEASE (GORD)
    A02BA H2-receptor antagonists
     A02BA07 Ranitidine bismuth citrate
      D05699  Ranitidine bismuth citrate (USAN)
USP drug classification [BR:br08302]
 Gastrointestinal Agents
  Histamine2 (H2) receptor Antagonists
   Ranitidine
    D05699  Ranitidine bismuth citrate (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H2-receptor
     Ranitidine bismuth citrate
      D05699  Ranitidine bismuth citrate (USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP inhbitors
  CYP2D6
   Ranitidine bismuth citrate
    D05699  Ranitidine bismuth citrate (USAN)
BRITE hierarchy
Other DBs
CAS: 
128345-62-0
PubChem: 
LigandBox: 
KCF data Show

ATOM        35
            1   C8y C    19.0764  -19.5690
            2   O2x O    20.1947  -20.4079
            3   C8x C    19.4958  -18.2410
            4   C1b C    17.8181  -20.2680
            5   C8y C    21.3131  -19.5690
            6   C8x C    20.8937  -18.2410
            7   N1c N    16.6297  -19.5690
            8   C1b C    22.5015  -20.2680
            9   C1a C    15.4415  -20.2680
            10  C1a C    16.6297  -18.1711
            11  S2a S    23.6898  -19.5690
            12  C1b C    24.9479  -20.2680
            13  C1b C    26.1363  -19.5690
            14  N1b N    27.3246  -20.2680
            15  C2c C    28.5828  -19.5690
            16  C2b C    29.7711  -20.2680
            17  N1b N    28.5828  -18.1711
            18  N2b N    30.9595  -19.5690 #+
            19  C1a C    27.3246  -17.4721
            20  O3a O    30.9595  -18.1711 #-
            21  O3a O    32.2177  -20.2680
            22  C1d C    29.4061  -24.8142
            23  C1b C    28.1950  -25.5105
            24  C1b C    30.6174  -25.5045
            25  C6a C    30.0966  -23.5970
            26  O1a O    28.6981  -23.5970
            27  C6a C    26.9895  -24.8200
            28  C6a C    30.6057  -26.9032
            29  O6a O    29.3885  -22.3801 #-
            30  O6a O    31.5010  -23.5970
            31  O6a O    25.7784  -25.5222 #-
            32  O6a O    27.0478  -23.4217
            33  O6a O    31.8170  -27.6053 #-
            34  O6a O    29.3885  -27.5994
            35  Z   Bi   22.4698  -25.4097 #3+
BOND        33
            1     1   2 1
            2     1   3 2
            3     1   4 1
            4     2   5 1
            5     3   6 1
            6     4   7 1
            7     5   8 1
            8     7   9 1
            9     7  10 1
            10    8  11 1
            11   11  12 1
            12   12  13 1
            13   13  14 1
            14   14  15 1
            15   15  16 2
            16   15  17 1
            17   16  18 1
            18   17  19 1
            19   18  20 1
            20   18  21 2
            21    5   6 2
            22   22  23 1
            23   22  24 1
            24   22  25 1
            25   22  26 1
            26   23  27 1
            27   24  28 1
            28   25  29 1
            29   25  30 2
            30   27  31 1
            31   27  32 2
            32   28  33 1
            33   28  34 2

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