KEGG   DRUG: D05819Help
Entry
D05819                      Drug                                   

Name
Semaxanib (USAN/INN)
Formula
C15H14N2O
Exact mass
238.1106
Mol weight
238.2845
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antineoplastic [anti-angiogenic by selective inhibition of vascular endothelial growth factor-mediated Flk-1 signaling]
Comment
angiogenesis inhibitor
Target
FLT3 inhibitor [HSA:2322] [KO:K05092];
VEGFR2 tyrosine kinase inhibitor [HSA:3791] [KO:K05098];
c-KIT inhibitor [HSA:3815] [KO:K05091]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04370  VEGF signaling pathway
hsa04510  Focal adhesion
hsa05200  Pathways in cancer  
 
Interaction
Drug interaction
Structure map
Antineoplastics - protein kinases inhibitors
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    c-KIT tyrosine kinase [HSA:3815] [KO:K05091]
     Semaxanib
      D05819  Semaxanib (USAN/INN)
    Fms-related tyrosine kinase 3 [HSA:2322] [KO:K05092]
     Semaxanib
      D05819  Semaxanib (USAN/INN)
   RTK class V (VEGF receptor family)
    VEGFR2 tyrosine kinase [HSA:3791] [KO:K05098]
     Semaxanib
      D05819  Semaxanib (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
194413-58-6
PubChem: 
LigandBox: 
KCF data Show

ATOM        18
            1   C8x C    17.9900  -18.9700
            2   C8x C    17.9900  -20.3700
            3   C8x C    19.1800  -21.0700
            4   C8y C    20.4400  -20.3700
            5   C8y C    20.4400  -18.9700
            6   C8x C    19.1800  -18.2700
            7   C2y C    21.7700  -20.7900
            8   C5x C    22.5400  -19.6700
            9   N1x N    21.7700  -18.5500
            10  O5x O    23.9400  -19.6700
            11  C2b C    21.7700  -22.1900
            12  C8y C    22.9600  -22.8900
            13  C8y C    22.9600  -24.2900
            14  C1a C    21.7000  -24.9900
            15  N4x N    24.2900  -22.4700
            16  C8y C    25.1300  -23.5900
            17  C8x C    24.2900  -24.7100
            18  C1a C    26.5300  -23.5900
BOND        20
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    5   9 1
            11    8  10 2
            12    7  11 2
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   12  15 1
            17   15  16 1
            18   16  17 2
            19   13  17 1
            20   16  18 1

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