KEGG   DRUG: D06005Help
Entry
D06005                      Drug                                   

Name
Tandutinib (USAN/INN)
Formula
C31H42N6O4
Exact mass
562.3268
Mol weight
562.703
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of cardiovascular diseases, fibrotic diseases and acute myelogenous leukemia [tyrosine kinase inhibitor]
Target
FLT3 inhibitor [HSA:2322] [KO:K05092];
PDGFRB tyrosine kinase inhibitor [HSA:5159] [KO:K05089];
c-KIT tyrosine kinase inhibitor [HSA:3815] [KO:K05091]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa05200  Pathways in cancer  
 
Interaction
Drug interaction
Structure map
Antineoplastics - protein kinases inhibitors
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRB tyrosine kinase
     Tandutinib
      D06005  Tandutinib (USAN/INN)
    c-KIT tyrosine kinase
     Tandutinib
      D06005  Tandutinib (USAN/INN)
    Fms-related tyrosine kinase 3
     Tandutinib
      D06005  Tandutinib (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
387867-13-2
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        41
            1   C8y C    19.1800  -15.4700
            2   C8y C    19.1800  -16.8700
            3   C8x C    17.9900  -17.5700
            4   C8y C    16.7300  -16.8700
            5   C8y C    16.7300  -15.4700
            6   C8x C    17.9900  -14.7700
            7   C8y C    15.5400  -17.5700
            8   N5x N    14.3500  -16.8700
            9   C8x C    14.3500  -15.4700
            10  N5x N    15.5400  -14.7700
            11  N1y N    15.5400  -18.9700
            12  O2a O    20.3953  -14.7749
            13  O2a O    20.3953  -17.5651
            14  C1a C    21.5837  -16.8723
            15  C1b C    21.5837  -15.4677
            16  C1b C    22.7801  -14.7835
            17  C1b C    23.9613  -15.4719
            18  N1y N    25.1613  -14.7855
            19  C1x C    26.3408  -15.4729
            20  C1x C    27.5560  -14.7778
            21  C1x C    27.5617  -13.3778
            22  C1x C    26.3822  -12.6905
            23  C1x C    25.0969  -13.3855
            24  C1x C    14.3276  -19.6700
            25  C1x C    14.3276  -21.0700
            26  N1y N    15.5400  -21.7700
            27  C1x C    16.7524  -21.0700
            28  C1x C    16.7524  -19.6700
            29  C5a C    15.5400  -23.1700
            30  O5a O    14.3276  -23.8700
            31  N1b N    16.7524  -23.8700
            32  C8y C    17.9479  -23.1796
            33  C8x C    19.1353  -23.8651
            34  C8x C    20.3477  -23.1650
            35  C8y C    20.3476  -21.7650
            36  C8x C    19.1603  -21.0796
            37  C8x C    17.9479  -21.7796
            38  O2a O    21.5745  -21.0564
            39  C1c C    22.7819  -21.7534
            40  C1a C    23.9631  -21.0712
            41  C1a C    22.7824  -23.1696
BOND        45
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    7  11 1
            13    1  12 1
            14    2  13 1
            15   13  14 1
            16   12  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 1
            24   22  23 1
            25   18  23 1
            26   11  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   27  28 1
            31   11  28 1
            32   26  29 1
            33   29  30 2
            34   29  31 1
            35   31  32 1
            36   32  33 2
            37   33  34 1
            38   34  35 2
            39   35  36 1
            40   36  37 2
            41   32  37 1
            42   35  38 1
            43   38  39 1
            44   39  40 1
            45   39  41 1

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