KEGG   DRUG: D06234Help
Entry
D06234                      Drug                                   

Name
Trimazosin hydrochloride (USAN);
Trimazosin hydrochloride monohydrate
Formula
C20H29N5O6. HCl. H2O
Exact mass
489.199
Mol weight
489.9504
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive
Remark
ATC code: 
Target
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02C ANTIADRENERGIC AGENTS, PERIPHERALLY ACTING
    C02CA Alpha-adrenoreceptor antagonists
     C02CA03 Trimazosin
      D06234  Trimazosin hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor [HSA:146 147 148] [KO:K04137 K04136 K04135]
     Trimazosin [ATC:C02CA03]
      D06234  Trimazosin hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
53746-46-6
PubChem: 
LigandBox: 
KCF data Show

ATOM        33
            1   C8y C    26.0129  -19.6598
            2   C8y C    26.0129  -18.2529
            3   C8x C    27.2389  -20.3662
            4   C8y C    24.8044  -20.3662
            5   N5x N    24.8044  -17.5697
            6   C8y C    27.2389  -17.5697
            7   C8y C    28.4415  -19.6598
            8   N5x N    23.5958  -19.6598
            9   N1a N    24.8044  -21.7674
            10  C8y C    23.5958  -18.2529
            11  C8y C    28.4415  -18.2529
            12  O2a O    29.6734  -20.3662
            13  N1y N    22.3873  -17.5697
            14  O2a O    29.6734  -17.5697
            15  C1a C    30.8762  -19.6539
            16  C1x C    22.3873  -16.1744
            17  C1x C    21.1671  -18.2529
            18  C1a C    30.8762  -18.2644
            19  C1x C    21.1671  -15.4679
            20  C1x C    19.9585  -17.5697
            21  N1y N    19.9585  -16.1744
            22  C7a C    18.7326  -15.4679
            23  O7a O    17.5181  -16.1744
            24  O6a O    18.7326  -14.0609
            25  O2a O    27.2446  -16.1701
            26  C1a C    28.4489  -15.4813
            27  C1b C    16.2879  -15.4694
            28  C1d C    15.0941  -16.1640
            29  C1a C    13.9009  -16.8583
            30  O1a O    14.3995  -14.9696
            31  C1a C    15.8071  -17.3898
            32  X   Cl   18.4800  -19.6700
            33  O0  O    18.9000  -21.2800
BOND        33
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 2
            7     4   8 2
            8     4   9 1
            9     5  10 2
            10    6  11 2
            11    7  12 1
            12   10  13 1
            13   11  14 1
            14   12  15 1
            15   13  16 1
            16   13  17 1
            17   14  18 1
            18   16  19 1
            19   17  20 1
            20   19  21 1
            21   21  22 1
            22   22  23 1
            23   22  24 2
            24    7  11 1
            25    8  10 1
            26   20  21 1
            27    6  25 1
            28   25  26 1
            29   23  27 1
            30   27  28 1
            31   28  29 1
            32   28  30 1
            33   28  31 1

» Japanese version   » Back

DBGET integrated database retrieval system