KEGG   DRUG: D06246Help
Entry
D06246                      Drug                                   

Name
Tripelennamine citrate;
PBZ (TN)
Formula
C16H21N3. C6H8O7
Exact mass
447.2006
Mol weight
447.4816
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihistaminic
Remark
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
CYP inhibition: CYP2D6 [HSA:1565]
Drug interaction
Structure map
Antipsychotics
Histamine H1 receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 D DERMATOLOGICALS
  D04 ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
   D04A ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
    D04AA Antihistamines for topical use
     D04AA04 Tripelennamine
      D06246  Tripelennamine citrate
 R RESPIRATORY SYSTEM
  R06 ANTIHISTAMINES FOR SYSTEMIC USE
   R06A ANTIHISTAMINES FOR SYSTEMIC USE
    R06AC Substituted ethylene diamines
     R06AC04 Tripelennamine
      D06246  Tripelennamine citrate
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Tripelennamine
      D06246  Tripelennamine citrate
Cytochrome P450 interactions [BR:br08309]
 Inhbitors
  CYP2D6
   Tripelennamine
    D06246  Tripelennamine citrate
BRITE hierarchy
Other DBs
CAS: 
6138-56-3
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        32
            1   C8x C     2.8182   -7.5277
            2   C8x C     2.8182   -8.9322
            3   C8x C     4.0345   -9.6345
            4   C8x C     5.2509   -8.9322
            5   C8y C     5.2509   -7.5277
            6   C8x C     4.0345   -6.8255
            7   N5x N     6.4672   -9.6345
            8   C8y C     7.6835   -8.9322
            9   N1c N     7.6835   -7.5277
            10  C1b C     6.4672   -6.8255
            11  C8x C     6.4672  -11.0390
            12  C8x C     7.6835  -11.7412
            13  C8x C     8.8999  -11.0390
            14  C8x C     8.8999   -9.6345
            15  C1b C     8.8849   -6.8340
            16  C1b C    10.0770   -7.5222
            17  N1c N    11.2716   -6.8324
            18  C1a C    12.4651   -7.5214
            19  C1a C    11.2716   -5.4212
            20  C1d C    18.7665   -8.6445
            21  C1b C    17.5553   -9.3408
            22  C1b C    19.9778   -9.3348
            23  C6a C    19.4570   -7.4273
            24  O1a O    18.0584   -7.4273
            25  C6a C    16.3498   -8.6503
            26  C6a C    19.9661  -10.7335
            27  O6a O    18.7489   -6.2103
            28  O6a O    20.8614   -7.4273
            29  O6a O    15.1387   -9.3525
            30  O6a O    16.4081   -7.2519
            31  O6a O    21.1774  -11.4356
            32  O6a O    18.7489  -11.4297
BOND        32
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     7   8 1
            8     8   9 1
            9     9  10 1
            10    5  10 1
            11    7  11 2
            12   11  12 1
            13   12  13 2
            14   13  14 1
            15    8  14 2
            16    9  15 1
            17   15  16 1
            18   16  17 1
            19   17  18 1
            20   17  19 1
            21   20  21 1
            22   20  22 1
            23   20  23 1
            24   20  24 1
            25   21  25 1
            26   22  26 1
            27   23  27 1
            28   23  28 2
            29   25  29 1
            30   25  30 2
            31   26  31 1
            32   26  32 2

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