KEGG   DRUG: ImidafenacinHelp
Entry
D06273                      Drug                                   

Name
Imidafenacin (JAN/INN);
Uritos (TN);
Staybla (TN)
Formula
C20H21N3O
Exact mass
319.1685
Mol weight
319.4002
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01491  Muscarinic cholinergic receptor antagonist
Cyp substrate
 DG01633  CYP3A substrate
Remark
Therapeutic category: 
Activity
Overactive bladder agent, Muscarinic antagonist
Target
CHRM1 [HSA:1128] [KO:K04129];
CHRM3 [HSA:1131] [KO:K04131]
  Pathway
Calcium signaling pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Salivary secretion
Gastric acid secretion
Pancreatic secretion
Metabolism
Enzyme: CYP3A4 [HSA:1576], UGT1A4 [HSA:54657]
Interaction
Drug interaction
Brite
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  25  Urogenital and anal organ agents
   259  Miscellaneous
    2590  Miscellaneous
     D06273  Imidafenacin (JAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Acetylcholine (muscarinic)
    muscarinic cholinergic receptor M1
     Imidafenacin
      D06273  Imidafenacin (JAN/INN)
    muscarinic cholinergic receptor M3
     Imidafenacin
      D06273  Imidafenacin (JAN/INN)
    muscarinic cholinergic receptor
     Imidafenacin
      D06273  Imidafenacin (JAN/INN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A4
   Imidafenacin
    D06273  Imidafenacin (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
170105-16-5
PubChem: 
LigandBox: 
KCF data Show

ATOM        24
            1   N5x N    26.6000  -18.6900
            2   C8x C    26.9623  -20.1123
            3   C8x C    28.3604  -20.1156
            4   N4y N    28.8622  -18.8085
            5   C8y C    27.7742  -17.9275
            6   C1b C    30.0524  -18.1300
            7   C1b C    31.2649  -18.8300
            8   C1d C    32.4773  -18.1300
            9   C8y C    33.6897  -18.8300
            10  C8y C    32.4773  -16.7300
            11  C8x C    33.6897  -20.2300
            12  C8x C    33.6918  -16.0288
            13  C8x C    33.6918  -14.6288
            14  C8x C    32.4793  -13.9288
            15  C8x C    31.2649  -14.6300
            16  C8x C    31.2649  -16.0300
            17  C8x C    34.9022  -20.9300
            18  C8x C    36.1146  -20.2300
            19  C8x C    36.1146  -18.8300
            20  C8x C    34.9022  -18.1300
            21  C5a C    35.5097  -16.4500
            22  C1a C    27.7742  -16.5275
            23  O5a O    36.6950  -17.1627
            24  N1a N    35.4645  -15.0507
BOND        26
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 1
            5     1   5 2
            6     4   6 1
            7     6   7 1
            8     7   8 1
            9     8   9 1
            10    8  10 1
            11    9  11 2
            12   10  12 2
            13   12  13 1
            14   13  14 2
            15   14  15 1
            16   15  16 2
            17   10  16 1
            18   11  17 1
            19   17  18 2
            20   18  19 1
            21   19  20 2
            22    9  20 1
            23    8  21 1
            24    5  22 1
            25   21  23 2
            26   21  24 1

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