KEGG   DRUG: D06274Help
Entry
D06274                      Drug                                   

Name
Tafluprost (JAN/USAN/INN);
Zioptan (TN)
Product
Formula
C25H34F2O5
Exact mass
452.2374
Mol weight
452.5313
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Glaucoma and ocular hypertension [DS:H00612]
Remark
Therapeutic category: 
ATC code: 
Target
prostaglandin F receptor agonist [HSA:5737] [KO:K04262]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Antiglaucoma agents
Eicosanoid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01E ANTIGLAUCOMA PREPARATIONS AND MIOTICS
    S01EE Prostaglandin analogues
     S01EE05 Tafluprost
      D06274  Tafluprost (JAN/USAN/INN)
USP drug classification [BR:br08302]
 Ophthalmic Agents
  Ophthalmic Prostaglandin and Prostamide Analogs
   Tafluprost
    D06274  Tafluprost (JAN/USAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  13  Agents affecting sensory organs
   131  Ophthalmic agents
    1319  Others
     D06274  Tafluprost (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Prostaglandin
    prostaglandin F receptor
     Tafluprost
      D06274  Tafluprost (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
209860-87-7
PubChem: 
LigandBox: 
KCF data Show

ATOM        32
            1   C1x C    11.4193  -14.3979
            2   C1y C    12.2620  -15.5917
            3   C1y C    13.5962  -15.1704
            4   C1y C    13.5962  -13.7660
            5   C1y C    12.2620  -13.2744
            6   C1b C    14.7197  -12.9233
            7   C2b C    15.9837  -13.5553
            8   C2b C    17.3881  -13.5553
            9   C1b C    18.5819  -12.8531
            10  C1b C    19.8458  -13.5553
            11  C1b C    21.0397  -12.8531
            12  C7a C    22.2335  -13.4851
            13  O7a O    23.4272  -12.8531
            14  O6a O    22.2335  -14.8895
            15  C1c C    24.6210  -13.4851
            16  C1a C    25.8147  -12.8531
            17  C1a C    24.6210  -14.8895
            18  C2b C    14.7280  -16.0000
            19  C2b C    15.9588  -15.3520
            20  C1d C    17.1397  -16.0966
            21  C1b C    18.3557  -15.4569
            22  O2a O    19.5432  -16.2062
            23  X   F    16.1466  -17.0896
            24  X   F    18.1328  -17.0896
            25  C8y C    19.5432  -17.6107
            26  C8x C    18.3360  -18.3079
            27  C8x C    18.3360  -19.7123
            28  C8x C    19.5525  -20.4143
            29  C8x C    20.7597  -19.7171
            30  C8x C    20.7595  -18.3127
            31  O1a O    11.8642  -11.9275
            32  O1a O    11.8134  -16.9226
BOND        33
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     1   5 1
            6     4   6 1 #Down
            7     6   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 1
            11   10  11 1
            12   11  12 1
            13   12  13 1
            14   12  14 2
            15   13  15 1
            16   15  16 1
            17   15  17 1
            18    3  18 1 #Up
            19   18  19 2
            20   19  20 1
            21   20  21 1
            22   21  22 1
            23   20  23 1
            24   20  24 1
            25   22  25 1
            26   25  26 2
            27   26  27 1
            28   27  28 2
            29   28  29 1
            30   29  30 2
            31   25  30 1
            32    5  31 1 #Down
            33    2  32 1 #Down

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