KEGG   DRUG: Varenicline tartrateHelp
Entry
D06282                      Drug                                   

Name
Varenicline tartrate (JAN/USAN);
Chantix (TN);
Champix (TN)
Product
Formula
C13H13N3. C4H6O6
Exact mass
361.1274
Mol weight
361.3493
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01571  Nicotinic cholinergic receptor partial agonist
Other
 DG01718  Drugs for addictive disorder
  DG01715  Drugs for nicotine dependence
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Smoking cessation adjunct, Selective nicotinic receptor modulator
Target
CHRNA4/CHRNB2 [HSA:1137 1141] [KO:K04806 K04813]
  Pathway
Neuroactive ligand-receptor interaction
Cholinergic synapse
Metabolism
Transporter: SLC22A2 [HSA:6582]
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07B DRUGS USED IN ADDICTIVE DISORDERS
    N07BA Drugs used in nicotine dependence
     N07BA03 Varenicline
      D06282  Varenicline tartrate (JAN/USAN)
USP drug classification [BR:br08302]
 Anti-Addiction/Substance Abuse Treatment Agents
  Smoking Cessation Agents
   Varenicline
    D06282  Varenicline tartrate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 7  Agents not mainly for therapeutic purpose
  79  Other agents not mainly for therapeutic purpose
   799  Miscellaneous
    7990  Miscellaneous
     D06282  Varenicline tartrate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Ion channels
  Cys-loop superfamily
   Acetylcholine (nicotinic)
    alpha4beta2 nicotinic receptor
     Varenicline
      D06282  Varenicline tartrate (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 Transporter substrates
  SLC22A2
   Varenicline
    D06282  Varenicline tartrate (JAN/USAN)
   Varenicline
    D06282  Varenicline tartrate (JAN/USAN)
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D06282
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06282
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D06282
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D06282
BRITE hierarchy
Other DBs
CAS: 
375815-87-5
PubChem: 
LigandBox: 
KCF data Show

ATOM        26
            1   C8y C     5.3200   -5.3900
            2   C1y C     4.2000   -4.4800
            3   C1x C     2.8700   -4.8300
            4   N1x N     2.2400   -6.0900
            5   C8y C     5.3200   -6.7900
            6   C1x C     2.8700   -7.3500
            7   C1y C     4.2000   -7.6300
            8   C8x C     6.5324   -7.4900
            9   C8y C     7.7449   -6.7900
            10  C8y C     7.7449   -5.3900
            11  C8x C     6.5324   -4.6900
            12  N5x N     8.9573   -7.4900
            13  C8x C    10.1697   -6.7900
            14  C8x C    10.1697   -5.3900
            15  N5x N     8.9573   -4.6900
            16  C1x C     3.5547   -6.0585
            17  O6a O    12.2731   -5.6706
            18  C6a C    13.4856   -6.3706
            19  C1c C    14.6981   -5.6706
            20  C1c C    15.9105   -6.3706
            21  C6a C    17.1231   -5.6706
            22  O6a O    18.3355   -6.3706
            23  O6a O    13.4856   -7.7705
            24  O1a O    14.6981   -4.2705
            25  O1a O    15.9105   -7.7706
            26  O6a O    17.1231   -4.2708
BOND        28
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     5   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    1  11 2
            13    9  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   10  15 1
            18    2  16 1
            19    7  16 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   21  22 1
            25   18  23 2
            26   19  24 1 #Down
            27   20  25 1 #Down
            28   21  26 2

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