KEGG   DRUG: VatalanibHelp
Entry
D06285                      Drug                                   

Name
Vatalanib (USAN/INN)
Formula
C20H15ClN4
Exact mass
346.0985
Mol weight
346.8129
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Efficacy
Antineoplastic, Angiogenesis inhibitor, Receptor tyrosine kinase inhibitor
Target
PDGFRB [HSA:5159] [KO:K05089]
VEGFR1 (FLT1) [HSA:2321] [KO:K05096]
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
VEGFR3 (FLT4) [HSA:2324] [KO:K05097]
KIT (CD117) [HSA:3815] [KO:K05091]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
hsa04370  VEGF signaling pathway
Interaction
Drug interaction
Structure map
map07045  Antineoplastics - protein kinases inhibitors
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   PDGFR family
    PDGFRB
     D06285  Vatalanib (USAN/INN)
    KIT (CD117)
     D06285  Vatalanib (USAN/INN)
   VEGFR family
    VEGFR1 (FLT1)
     D06285  Vatalanib (USAN/INN)
    VEGFR2 (KDR)
     D06285  Vatalanib (USAN/INN)
    VEGFR3 (FLT4)
     D06285  Vatalanib (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 212141-54-3
PubChem: 47207942
ChEBI: 90620
ChEMBL: CHEMBL101253
LigandBox: D06285
KCF data Show

ATOM        25
            1   C8x C    20.3121  -19.0002
            2   C8x C    20.3121  -20.4008
            3   C8x C    21.5280  -21.1011
            4   C8x C    21.5280  -18.3000
            5   C8y C    22.7367  -19.0002
            6   C8y C    22.7308  -20.4008
            7   C8y C    23.9407  -21.1061
            8   N5x N    25.1566  -20.4111
            9   N5x N    25.1625  -19.0106
            10  C8y C    23.9526  -18.3053
            11  N1b N    23.9585  -16.9047
            12  C8y C    25.1746  -16.2095
            13  C8x C    26.4164  -16.9331
            14  C8x C    27.6316  -16.2380
            15  C8y C    27.6373  -14.8380
            16  C8x C    26.3954  -14.1144
            17  C8x C    25.1802  -14.8095
            18  X   Cl   28.8612  -14.1378
            19  C1b C    23.9346  -22.5400
            20  C8y C    25.1481  -23.2475
            21  C8x C    25.1421  -24.6399
            22  C8x C    26.3515  -25.3452
            23  N5x N    27.5669  -24.6504
            24  C8x C    27.5729  -23.2580
            25  C8x C    26.3635  -22.5527
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   6 2
            4     5   4 2
            5     5   6 1
            6     6   7 1
            7     7   8 2
            8     8   9 1
            9     9  10 2
            10   10   5 1
            11    4   1 1
            12   10  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   12  17 1
            20   15  18 1
            21    7  19 1
            22   19  20 1
            23   20  21 2
            24   21  22 1
            25   22  23 2
            26   23  24 1
            27   24  25 2
            28   20  25 1

» Japanese version   » Back

DBGET integrated database retrieval system