KEGG   DRUG: VatalanibHelp
Entry
D06285                      Drug                                   

Name
Vatalanib (USAN/INN)
Formula
C20H15ClN4
Exact mass
346.0985
Mol weight
346.8129
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Activity
Antineoplastic, Tyrosine kinase inhibitor
Comment
angiogenesis inhibitor
Target
PDGFRB tyrosine kinase [HSA:5159] [KO:K05089];
VEGFR1 tyrosine kinase [HSA:2321] [KO:K05096];
VEGFR2 tyrosine kinase [HSA:3791] [KO:K05098];
VEGFR3 tyrosine kinase [HSA:2324] [KO:K05097];
KIT tyrosine kinase [HSA:3815] [KO:K05091]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
VEGF signaling pathway
Pathways in cancer
Structure map
Antineoplastics - protein kinases inhibitors
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRB tyrosine kinase
     Vatalanib
      D06285  Vatalanib (USAN/INN)
    c-KIT tyrosine kinase
     Vatalanib
      D06285  Vatalanib (USAN/INN)
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase
     Vatalanib
      D06285  Vatalanib (USAN/INN)
    VEGFR2 tyrosine kinase
     Vatalanib
      D06285  Vatalanib (USAN/INN)
    VEGFR3 tyrosine kinase
     Vatalanib
      D06285  Vatalanib (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
212141-54-3
PubChem: 
LigandBox: 
KCF data Show

ATOM        25
            1   C8x C    20.3121  -19.0002
            2   C8x C    20.3121  -20.4008
            3   C8x C    21.5280  -21.1011
            4   C8x C    21.5280  -18.3000
            5   C8y C    22.7367  -19.0002
            6   C8y C    22.7308  -20.4008
            7   C8y C    23.9407  -21.1061
            8   N5x N    25.1566  -20.4111
            9   N5x N    25.1625  -19.0106
            10  C8y C    23.9526  -18.3053
            11  N1b N    23.9585  -16.9047
            12  C8y C    25.1746  -16.2095
            13  C8x C    26.4164  -16.9331
            14  C8x C    27.6316  -16.2380
            15  C8y C    27.6373  -14.8380
            16  C8x C    26.3954  -14.1144
            17  C8x C    25.1802  -14.8095
            18  X   Cl   28.8612  -14.1378
            19  C1b C    23.9346  -22.5400
            20  C8y C    25.1481  -23.2475
            21  C8x C    25.1421  -24.6399
            22  C8x C    26.3515  -25.3452
            23  N5x N    27.5669  -24.6504
            24  C8x C    27.5729  -23.2580
            25  C8x C    26.3635  -22.5527
BOND        28
            1     1   2 2
            2     2   3 1
            3     3   6 2
            4     5   4 2
            5     5   6 1
            6     6   7 1
            7     7   8 2
            8     8   9 1
            9     9  10 2
            10   10   5 1
            11    4   1 1
            12   10  11 1
            13   11  12 1
            14   12  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18   16  17 2
            19   12  17 1
            20   15  18 1
            21    7  19 1
            22   19  20 1
            23   20  21 2
            24   21  22 1
            25   22  23 2
            26   23  24 1
            27   24  25 2
            28   20  25 1

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