KEGG   DRUG: D06390Help
Entry
D06390                      Drug                                   

Name
Azithromycin (USP);
AZM;
Zmax (TN)
Product
  Generic
AZITHROMYCIN (Aphena Pharma Solutions - Tennessee), AZITHROMYCIN (Cardinal Health), AZITHROMYCIN (Cardinal Health), AZITHROMYCIN (Clinical Solutions Wholesale), AZITHROMYCIN (Clinical Solutions Wholesale), AZITHROMYCIN (Clinical Solutions Wholesale), AZITHROMYCIN (DIRECT RX), AZITHROMYCIN (KAISER FOUNDATION HOSPITALS), AZITHROMYCIN (Lake Erie Medical & Surgical Supply DBA Quality Care Products LLC), AZITHROMYCIN (McKesson Packaging Services a Business Unit of McKesson Corporation), AZITHROMYCIN (MedVantx), AZITHROMYCIN (MedVantx), AZITHROMYCIN (PD-Rx Pharmaceuticals), AZITHROMYCIN (Physicians Total Care), AZITHROMYCIN (Pliva), AZITHROMYCIN (Pliva), AZITHROMYCIN (Preferred Pharmaceuticals), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (Proficient Rx LP), AZITHROMYCIN (REMEDYREPACK), AZITHROMYCIN (REMEDYREPACK), AZITHROMYCIN (REMEDYREPACK), AZITHROMYCIN (Sandoz), AZITHROMYCIN (Sandoz), AZITHROMYCIN (Sun Pharmaceutical Industries Limited), AZITHROMYCIN (Teva Pharmaceuticals USA), AZITHROMYCIN (Teva Pharmaceuticals USA), AZITHROMYCIN (Teva Pharmaceuticals USA), AZITHROMYCIN (Unit Dose Services), AZITHROMYCIN (APOTEX CORP.), AZITHROMYCIN (Cardinal Health), AZITHROMYCIN (Fresenius Kabi USA), AZITHROMYCIN (Fresenius Kabi USA), AZITHROMYCIN (Fresenius Kabi USA), AZITHROMYCIN (Hospira), AZITHROMYCIN (Hospira), AZITHROMYCIN (MedVantx), AZITHROMYCIN (Physicians Total Care), AZITHROMYCIN (Preferred Pharmaceuticals), AZITHROMYCIN (REMEDYREPACK), AZITHROMYCIN (REMEDYREPACK), AZITHROMYCIN (Rebel Distributors Corp.), AZITHROMYCIN (Sagent Pharmaceuticals), AZITHROMYCIN (Teva Pharmaceuticals USA)
Formula
C38H72N2O12. xH2O
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antibacterial
Remark
ATC code: 
Drug group: 
Comment
Semisynthetic macrolide
Target
23S rRNA of 50S ribosomal subunit, protein synthesis inhibitor [KO:K01980]
  Pathway
ko03010  Ribosome  
 
Metabolism
Transporter: ABCB1 [HSA:5243]
Interaction
Transporter inhibition: ABCB1 [HSA:5243]
Drug interaction
Structure map
Macrolides and ketolides
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J01 ANTIBACTERIALS FOR SYSTEMIC USE
   J01F MACROLIDES, LINCOSAMIDES AND STREPTOGRAMINS
    J01FA Macrolides
     J01FA10 Azithromycin
      D06390  Azithromycin (USP)
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01A ANTIINFECTIVES
    S01AA Antibiotics
     S01AA26 Azithromycin
      D06390  Azithromycin (USP)
USP drug classification [BR:br08302]
 Antibacterials
  Macrolides
   Azithromycin
    D06390  Azithromycin (USP)
Antiinfectives [BR:br08307]
 Antibacterials
  Protein biosynthesis inhibitor
   23S rRNA of 50S ribosomal subunit inhibitor
    Macrolides
     Azithromycin
      D06390  Azithromycin (USP)
BRITE hierarchy
Other DBs
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        53
            1   C1y C    22.6580  -16.6914
            2   C1y C    21.4463  -17.3176
            3   O2a O    24.2209  -17.6570
            4   C1z C    22.7046  -15.3624
            5   C1y C    21.4462  -18.6405
            6   C1a C    20.6374  -16.2886
            7   C1y C    25.5732  -16.8903
            8   C1x C    21.9087  -14.7889
            9   C1a C    23.8698  -15.9186
            10  O1a O    23.8815  -14.6425
            11  O2a O    22.1837  -20.5664
            12  C1y C    20.2930  -19.2846
            13  C1y C    26.2990  -18.1312
            14  O2x O    26.2873  -15.6375
            15  C1y C    22.3887  -13.5242
            16  C1y C    23.7876  -21.2806
            17  C7x C    19.1690  -18.5879
            18  C1a C    20.2637  -20.6075
            19  C1y C    27.7334  -18.1195
            20  O1a O    25.5849  -19.3841
            21  C1y C    27.7274  -15.6375
            22  C1x C    21.5926  -12.7049
            23  C1a C    23.4074  -12.9684
            24  C1x C    23.7876  -22.7265
            25  O2x O    25.0289  -20.5664
            26  O7x O    19.1925  -17.2650
            27  O6a O    18.2146  -19.5655
            28  C1x C    28.4416  -16.8786
            29  N1c N    28.4533  -19.3664
            30  C1a C    28.4416  -14.3907
            31  N1y N    20.3751  -12.6639
            32  C1z C    25.0289  -23.4407
            33  C1y C    26.2755  -21.2806
            34  C1y C    18.0627  -16.5917
            35  C1a C    29.8174  -20.2738
            36  C1a C    29.7470  -18.6699
            37  C1y C    19.2219  -13.2902
            38  C1a C    20.4041  -11.2941
            39  C1y C    26.2755  -22.7265
            40  O2a O    25.0172  -24.7754
            41  C1a C    27.5166  -20.5664
            42  C1z C    18.0511  -15.2630
            43  C1b C    16.9038  -17.2124
            44  C1y C    19.2160  -14.6308
            45  C1a C    18.0628  -12.6112
            46  O1a O    27.5166  -23.4407
            47  C1a C    26.1703  -25.4544
            48  C1a C    16.7634  -15.7723
            49  O1a O    16.9038  -14.1742
            50  C1a C    16.8744  -18.5410
            51  O1a O    20.3633  -15.3039
            52  C1a C    23.8163  -24.1408
            53  O0  O    32.1300  -23.5900
BOND        54
            1     1   2 1
            2     1   3 1 #Down
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     7   3 1 #Down
            7     4   8 1
            8     4   9 1 #Down
            9     4  10 1 #Up
            10    5  11 1 #Down
            11    5  12 1
            12    7  13 1
            13    7  14 1
            14    8  15 1
            15   16  11 1 #Down
            16   12  17 1
            17   12  18 1 #Up
            18   13  19 1
            19   13  20 1 #Up
            20   14  21 1
            21   15  22 1
            22   15  23 1 #Down
            23   16  24 1
            24   16  25 1
            25   17  26 1
            26   17  27 2
            27   19  28 1
            28   19  29 1 #Down
            29   21  30 1 #Down
            30   22  31 1
            31   24  32 1
            32   25  33 1
            33   26  34 1
            34   29  35 1
            35   29  36 1
            36   31  37 1
            37   31  38 1
            38   32  39 1
            39   32  40 1 #Down
            40   33  41 1 #Up
            41   34  42 1
            42   34  43 1 #Down
            43   37  44 1
            44   37  45 1 #Up
            45   39  46 1 #Down
            46   40  47 1
            47   42  48 1 #Down
            48   42  49 1 #Up
            49   43  50 1
            50   44  51 1 #Up
            51   21  28 1
            52   33  39 1
            53   42  44 1
            54   32  52 1 #Up
BRACKET     1    30.1000  -24.6400   30.1000  -22.4000
            1    32.7600  -22.4000   32.7600  -24.6400
            1  x
 ORIGINAL  1   53
 REPEAT    1

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