KEGG   DRUG: Sunitinib malateHelp
Entry
D06402                      Drug                                   

Name
Sunitinib malate (JAN/USAN);
Sutent (TN)
Product
Formula
C22H27FN4O2. C4H6O5
Exact mass
532.2333
Mol weight
532.5612
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Remark
Therapeutic category: 
ATC code: 
Chemical group: 
Activity
Antineoplastic
  Disease
Gastrotintestinal stromal tumor [DS:H01591]
Renal cell carcinoma [DS:H00021]
Pancreatic neuroendocrine tumors [DS:H00045]
Target
CSF1 [HSA:1435] [KO:K05453];
FLT3 kinase [HSA:2322] [KO:K05092];
PDGFRA tyrosine kinase [HSA:5156] [KO:K04363];
PDGFRB tyrosine kinase [HSA:5159] [KO:K05089];
RET [HSA:5979] [KO:K05126];
VEGFR1 tyrosine kinase [HSA:2321] [KO:K05096];
VEGFR2 tyrosine kinase [HSA:3791] [KO:K05098];
VEGFR3 tyrosine kinase [HSA:2324] [KO:K05097];
KIT tyrosine kinase [HSA:3815] [KO:K05091]
  Pathway
MAPK signaling pathway
Calcium signaling pathway
Cytokine-cytokine receptor interaction
VEGF signaling pathway
Pathways in cancer
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Antineoplastics - protein kinases inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XE Protein kinase inhibitors
     L01XE04 Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Sunitinib
    D06402  Sunitinib malate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D06402  Sunitinib malate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRA tyrosine kinase
     Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
    PDGFRB tyrosine kinase
     Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
    c-KIT tyrosine kinase
     Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
    Fms-related tyrosine kinase 3
     Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase
     Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
    VEGFR2 tyrosine kinase
     Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
    VEGFR3 tyrosine kinase
     Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
   RTK class XIV (RET receptor family)
    RET
     Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
 Cytokines
  PDGF family
   CSF1
    Sunitinib
     D06402  Sunitinib malate (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 CYP substrates
  CYP3A4
   Sunitinib
    D06402  Sunitinib malate (JAN/USAN)
Antineoplastics [br08340.html]
 D06402
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D06402
BRITE hierarchy
Other DBs
CAS: 
341031-54-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        38
            1   C8x C    41.1025  -27.7475
            2   C8x C    39.9075  -28.4505
            3   C8y C    39.9075  -29.8564
            4   C8x C    41.1025  -30.5593
            5   C8y C    42.2975  -29.8564
            6   C8y C    42.2975  -28.4505
            7   C2y C    43.7033  -30.2781
            8   C5x C    44.4766  -29.1535
            9   N1x N    43.7033  -28.0288
            10  X   F    38.7126  -30.5593
            11  O5x O    45.8824  -29.1535
            12  C2b C    43.7033  -31.6839
            13  C8y C    44.8983  -32.3869
            14  C8y C    44.8983  -33.7928
            15  C8y C    46.2339  -34.2145
            16  C8y C    47.0071  -33.0899
            17  N4x N    46.2339  -31.9652
            18  C1a C    43.7033  -34.6362
            19  C1a C    48.4130  -33.0899
            20  C5a C    46.2339  -35.6203
            21  O5a O    45.0165  -36.3233
            22  N1b N    47.4514  -36.3233
            23  C1b C    48.6519  -35.6301
            24  C1b C    49.8443  -36.3184
            25  N1c N    51.0404  -35.6276
            26  C1b C    52.2349  -36.3171
            27  C1a C    53.4300  -35.6270
            28  C1b C    51.0404  -34.2148
            29  C1a C    52.2379  -33.5231
            30  C1c C    51.9013  -29.3983
            31  C1b C    53.1022  -30.0910
            32  C6a C    50.7070  -30.0910
            33  O1a O    51.9013  -28.0135
            34  C6a C    54.2965  -29.3983
            35  O6a O    49.5126  -29.3921
            36  O6a O    50.7132  -31.6079
            37  O6a O    55.4909  -30.0910
            38  O6a O    54.2902  -28.0135
BOND        39
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    6   9 1
            11    3  10 1
            12    8  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   13  17 1
            20   14  18 1
            21   16  19 1
            22   15  20 1
            23   20  21 2
            24   20  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   25  28 1
            31   28  29 1
            32   30  31 1
            33   30  32 1
            34   30  33 1 #Up
            35   31  34 1
            36   32  35 1
            37   32  36 2
            38   34  37 1
            39   34  38 2

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