KEGG   DRUG: D06402Help
Entry
D06402                      Drug                                   

Name
Sunitinib malate (JAN/USAN);
Sutent (TN)
Product
Formula
C22H27FN4O2. C4H6O5
Exact mass
532.2333
Mol weight
532.5612
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of cancer [DS:H00021]
Remark
Therapeutic category: 
ATC code: 
Drug group: 
Target
CSF1 inhibitor [HSA:1435] [KO:K05453];
FLT3 inhibitor [HSA:2322] [KO:K05092];
PDGFRA tyrosine kinase inhibitor [HSA:5156] [KO:K04363];
PDGFRB tyrosine kinase inhibitor [HSA:5159] [KO:K05089];
RET inhibitor [HSA:5979] [KO:K05126];
VEGFR1 tyrosine kinase inhibitor [HSA:2321] [KO:K05096];
VEGFR2 tyrosine kinase inhibitor [HSA:3791] [KO:K05098];
VEGFR3 tyrosine kinase inhibitor [HSA:2324] [KO:K05097];
c-KIT tyrosine kinase inhibitor [HSA:3815] [KO:K05091]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04370  VEGF signaling pathway
hsa05200  Pathways in cancer  
 
Metabolism
Enzyme: CYP3A4 [HSA:1576]
Interaction
Drug interaction
Structure map
Antineoplastics - protein kinases inhibitors
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XE Protein kinase inhibitors
     L01XE04 Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
USP drug classification [BR:br08302]
 Antineoplastics
  Molecular Target Inhibitors
   Sunitinib
    D06402  Sunitinib malate (JAN/USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D06402  Sunitinib malate (JAN/USAN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRA tyrosine kinase
     Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
    PDGFRB tyrosine kinase
     Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
    c-KIT tyrosine kinase
     Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
    Fms-related tyrosine kinase 3
     Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase
     Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
    VEGFR2 tyrosine kinase
     Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
    VEGFR3 tyrosine kinase
     Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
   RTK class XIV (RET receptor family)
    RET
     Sunitinib
      D06402  Sunitinib malate (JAN/USAN)
 Cytokines
  PDGF family
   CSF1
    Sunitinib
     D06402  Sunitinib malate (JAN/USAN)
Antineoplastics [BR:br08308]
 Molecularly targeted agents
  Receptor tyrosine kinase inhibitor
   Sunitinib
    D06402  Sunitinib malate (JAN/USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP3A4
   Sunitinib
    D06402  Sunitinib malate (JAN/USAN)
BRITE hierarchy
Other DBs
CAS: 
341031-54-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        38
            1   C8x C    41.1025  -27.7475
            2   C8x C    39.9075  -28.4505
            3   C8y C    39.9075  -29.8564
            4   C8x C    41.1025  -30.5593
            5   C8y C    42.2975  -29.8564
            6   C8y C    42.2975  -28.4505
            7   C2y C    43.7033  -30.2781
            8   C5x C    44.4766  -29.1535
            9   N1x N    43.7033  -28.0288
            10  X   F    38.7126  -30.5593
            11  O5x O    45.8824  -29.1535
            12  C2b C    43.7033  -31.6839
            13  C8y C    44.8983  -32.3869
            14  C8y C    44.8983  -33.7928
            15  C8y C    46.2339  -34.2145
            16  C8y C    47.0071  -33.0899
            17  N4x N    46.2339  -31.9652
            18  C1a C    43.7033  -34.6362
            19  C1a C    48.4130  -33.0899
            20  C5a C    46.2339  -35.6203
            21  O5a O    45.0165  -36.3233
            22  N1b N    47.4514  -36.3233
            23  C1b C    48.6519  -35.6301
            24  C1b C    49.8443  -36.3184
            25  N1c N    51.0404  -35.6276
            26  C1b C    52.2349  -36.3171
            27  C1a C    53.4300  -35.6270
            28  C1b C    51.0404  -34.2148
            29  C1a C    52.2379  -33.5231
            30  C1c C    51.9013  -29.3983
            31  C1b C    53.1022  -30.0910
            32  C6a C    50.7070  -30.0910
            33  O1a O    51.9013  -28.0135
            34  C6a C    54.2965  -29.3983
            35  O6a O    49.5126  -29.3921
            36  O6a O    50.7132  -31.6079
            37  O6a O    55.4909  -30.0910
            38  O6a O    54.2902  -28.0135
BOND        39
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 1
            10    6   9 1
            11    3  10 1
            12    8  11 2
            13    7  12 2
            14   12  13 1
            15   13  14 2
            16   14  15 1
            17   15  16 2
            18   16  17 1
            19   13  17 1
            20   14  18 1
            21   16  19 1
            22   15  20 1
            23   20  21 2
            24   20  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 1
            28   25  26 1
            29   26  27 1
            30   25  28 1
            31   28  29 1
            32   30  31 1
            33   30  32 1
            34   30  33 1 #Up
            35   31  34 1
            36   32  35 1
            37   32  36 2
            38   34  37 1
            39   34  38 2

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