KEGG   DRUG: BevacizumabHelp
Entry
D06409                      Drug                                   

Name
Bevacizumab (USAN);
Bevacizumab (genetical recombination) (JAN);
Avastin (TN)
Product
Formula
C6638H10160N1720O2108S44
Exact mass
149104.8407
Mol weight
149196.8162
Remark
Therapeutic category: 
ATC code: 
Activity
Antineoplastic, Angiogenesis inhibitor, Anti-VEGF antibody
  Disease
Colorectal cancer [DS:H00020]
Non-squamous non-small cell lung cancer [DS:H00014]
Glioblastoma [DS:H00042]
Renal cell carcinoma [DS:H00021]
Carcinoma of the cervix [DS:H00030]
Epithelial ovarian, fallopian tube or primary peritoneal cancer [DS:H00027 H01554 H01665]
Target
VEGFA [HSA:7422] [KO:K05448]
  Pathway
Cytokine-cytokine receptor interaction
mTOR signaling pathway
VEGF signaling pathway
Pathways in cancer
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L01 ANTINEOPLASTIC AGENTS
   L01X OTHER ANTINEOPLASTIC AGENTS
    L01XC Monoclonal antibodies
     L01XC07 Bevacizumab
      D06409  Bevacizumab (USAN)
Therapeutic category of drugs in Japan [BR:br08301]
 4  Agents affecting cellular function
  42  Antineoplastics
   429  Miscellaneous
    4291  Other Antitumors
     D06409  Bevacizumab (USAN); Bevacizumab (genetical recombination) (JAN)
Target-based classification of drugs [BR:br08310]
 Cytokines
  PDGF family
   VEGFA
    Bevacizumab
     D06409  Bevacizumab (USAN)
Antineoplastics [br08340.html]
 D06409
New drug approvals in the USA [br08319.html]
 New Molecular Entity and New Therapeutic Biological Product Approvals
  D06409
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D06409
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D06409
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D06409
Orphan drugs in the USA [br08355.html]
 Orphan drugs in the USA
  D06409
BRITE hierarchy
Other DBs
CAS: 
216974-75-3
PubChem: 
DrugBank: 
NIKKAJI: 

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