KEGG   DRUG: D06517Help
Entry
D06517                      Drug                                   

Name
Pirmenol hydrochloride (USAN);
Pirmavar (TN)
Formula
C22H30N2O. HCl
Exact mass
374.2125
Mol weight
374.9473
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Cardiac depressant [anti-arrhythmic]
Remark
Drug group: 
Comment
Class I antiarrhythmic agent (Ia)
Target
voltage-gated sodium channel (SCN1A) blocker [HSA:6323] [KO:K04833];
voltage-gated sodium channel (SCN2A) blocker [HSA:6326] [KO:K04834];
voltage-gated sodium channel (SCN3A) blocker [HSA:6328] [KO:K04836];
voltage-gated sodium channel (SCN4A) blocker [HSA:6329] [KO:K04837];
voltage-gated sodium channel (SCN5A) blocker [HSA:6331] [KO:K04838];
voltage-gated sodium channel (SCN8A) blocker [HSA:6334] [KO:K04840];
voltage-gated sodium channel (SCN9A) blocker [HSA:6335] [KO:K04841]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
Sodium channel blocking drugs
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Voltage-gated cation channels
   Na+ channel, SCN alpha, NaV1.x
    voltage-gated sodium channel (SCN1A)
     Pirmenol
      D06517  Pirmenol hydrochloride (USAN)
    voltage-gated sodium channel (SCN2A)
     Pirmenol
      D06517  Pirmenol hydrochloride (USAN)
    voltage-gated sodium channel (SCN3A)
     Pirmenol
      D06517  Pirmenol hydrochloride (USAN)
    voltage-gated sodium channel (SCN4A)
     Pirmenol
      D06517  Pirmenol hydrochloride (USAN)
    voltage-gated sodium channel (SCN5A)
     Pirmenol
      D06517  Pirmenol hydrochloride (USAN)
    voltage-gated sodium channel (SCN8A)
     Pirmenol
      D06517  Pirmenol hydrochloride (USAN)
    voltage-gated sodium channel (SCN9A)
     Pirmenol
      D06517  Pirmenol hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
61477-94-9
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        26
            1   C8x C    26.8663  -19.6226
            2   C8x C    26.8663  -21.0243
            3   C8x C    28.0831  -21.7251
            4   C8x C    29.2928  -21.0243
            5   C8y C    29.2928  -19.6226
            6   C8x C    28.0831  -18.9218
            7   C1d C    30.5072  -18.9228
            8   C8y C    31.7206  -19.6245
            9   C8x C    31.7140  -21.0241
            10  C8x C    32.9274  -21.7260
            11  C8x C    34.1417  -21.0260
            12  C8x C    34.1427  -19.6243
            13  N5x N    32.9295  -18.9226
            14  C1b C    30.5050  -17.5273
            15  C1b C    31.7155  -16.8265
            16  C1b C    31.7155  -15.4319
            17  N1y N    32.9261  -14.7311
            18  C1y C    34.1383  -15.4290
            19  C1x C    35.3489  -14.7282
            20  C1x C    35.3472  -13.3294
            21  C1x C    34.1349  -12.6315
            22  C1y C    32.9244  -13.3323
            23  C1a C    31.7096  -12.6328
            24  C1a C    34.1400  -16.8307
            25  O1a O    29.2948  -18.2228
            26  X   Cl   37.2767  -18.6182
BOND        27
            1    11  12 1
            2    12  13 2
            3    13   8 1
            4     6   1 1
            5     7  14 1
            6    14  15 1
            7     5   7 1
            8    15  16 1
            9    16  17 1
            10    7   8 1
            11    1   2 2
            12    2   3 1
            13    3   4 2
            14    4   5 1
            15    5   6 2
            16   17  18 1
            17   18  19 1
            18   19  20 1
            19   20  21 1
            20   21  22 1
            21   22  17 1
            22    8   9 2
            23   22  23 1 #Down
            24    9  10 1
            25   18  24 1 #Down
            26   10  11 2
            27    7  25 1

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