KEGG   DRUG: D06552Help
Entry
D06552                      Drug                                   

Name
Alcaftadine (JAN/USAN/INN);
Lastacaft (TN)
Product
Formula
C19H21N3O
Exact mass
307.1685
Mol weight
307.3895
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-allergic, histaminic H1 receptor antagonist, anti-inflammatory
Remark
ATC code: 
Drug group: 
Target
H1-receptor antagonist [HSA:3269] [KO:K04149]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 S SENSORY ORGANS
  S01 OPHTHALMOLOGICALS
   S01G DECONGESTANTS AND ANTIALLERGICS
    S01GX Other antiallergics
     S01GX11 Alcaftadine
      D06552  Alcaftadine (JAN/USAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Histamine
    H1-receptor
     Alcaftadine
      D06552  Alcaftadine (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
147084-10-4
PubChem: 
LigandBox: 
KCF data Show

ATOM        23
            1   C1x C    31.5634  -17.2994
            2   C8y C    30.7213  -16.1898
            3   C8y C    31.0565  -14.8330
            4   C2y C    32.3175  -14.2549
            5   C1x C    32.9692  -17.3246
            6   C8y C    33.5711  -14.8772
            7   N4y N    33.8576  -16.2459
            8   C8x C    30.0494  -13.8646
            9   C8x C    28.7074  -14.2527
            10  C8x C    28.3722  -15.6095
            11  C8x C    29.3793  -16.5776
            12  C8y C    35.2479  -16.3964
            13  C8x C    35.8206  -15.1206
            14  N5x N    34.7843  -14.1818
            15  C2y C    32.3392  -12.8800
            16  C1x C    33.6332  -12.1989
            17  C1x C    33.5852  -10.7991
            18  N1y N    32.3840  -10.0800
            19  C1x C    31.1601  -10.7611
            20  C1x C    31.1380  -12.1610
            21  C1a C    32.4061   -8.6800
            22  C4a C    35.9448  -17.6121
            23  O4a O    37.3448  -17.6121
BOND        26
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 2
            9     8   9 1
            10    9  10 2
            11   10  11 1
            12    2  11 2
            13    7  12 1
            14   12  13 2
            15   13  14 1
            16    6  14 2
            17    4  15 2
            18   15  16 1
            19   16  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   15  20 1
            24   18  21 1
            25   12  22 1
            26   22  23 2

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