KEGG   DRUG: D06613Help
Entry
D06613                      Drug                                   

Name
Lorcaserin hydrochloride (USAN);
APD-356;
Belviq (TN)
Product
Formula
C11H14ClN. HCl
Exact mass
231.0582
Mol weight
232.1495
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anti-obesity [activate 5-HT2c]
Remark
ATC code: 
Target
5-HT2C-receptor agonist [HSA:3358] [KO:K04157]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04726  Serotonergic synapse  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A08 ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
   A08A ANTIOBESITY PREPARATIONS, EXCL. DIET PRODUCTS
    A08AA Centrally acting antiobesity products
     A08AA11 Lorcaserin
      D06613  Lorcaserin hydrochloride (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Serotonin
    5-HT2-receptor [HSA:3356 3357 3358] [KO:K04157]
     Lorcaserin
      D06613  Lorcaserin hydrochloride (USAN)
BRITE hierarchy
Other DBs
CAS: 
846589-98-8
PubChem: 
LigandBox: 
KCF data Show

ATOM        14
            1   C1x C    31.5634  -17.2994
            2   C1y C    30.7213  -16.1898
            3   C8y C    31.0565  -14.8330
            4   C8y C    32.3175  -14.2549
            5   N1x N    32.9692  -17.3246
            6   C1x C    33.5711  -14.8772
            7   C1x C    33.8576  -16.2459
            8   C1a C    29.3793  -16.5776
            9   C8x C    32.3175  -12.8549
            10  C8x C    31.1327  -12.1712
            11  C8y C    29.9297  -12.8662
            12  X   Cl   28.7458  -12.1831
            13  C8x C    29.9298  -14.2797
            14  X   Cl   36.8900  -14.4200
BOND        14
            1     3   4 1
            2     1   5 1
            3     4   6 1
            4     2   3 1
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     2   8 1 #Down
            9     4   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   11  13 1
            14    3  13 2

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