KEGG   DRUG: D06623Help
Entry
D06623                      Drug                                   

Name
Olanzapine pamoate (USAN);
Olanzapine pamoate monohydrate
Product
Formula
C23H16O6. C17H20N4S. H2O
Exact mass
718.2461
Mol weight
718.8173
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of schizophrenia [selective monoaminergic antagonist]
Remark
ATC code: 
Drug group: 
Comment
Multi-acting-receptor-targeting-antipsychotics (MARTA)
Target
5-HT2A-receptor antagonist [HSA:3356] [KO:K04157];
5-HT2C-receptor antagonist [HSA:3358] [KO:K04157];
H1-receptor antagonist [HSA:3269] [KO:K04149];
alpha1-adrenergic receptor antagonist [HSA:146 147 148] [KO:K04137 K04136 K04135];
dopamine D2-receptor antagonist [HSA:1813] [KO:K04145];
dopamine D3-receptor antagonist [HSA:1814] [KO:K04146];
dopamine D4-receptor antagonist [HSA:1815] [KO:K04147]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04540  Gap junction
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: CYP1A2 [HSA:1544], CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Serotonin receptor agonists/antagonists
Dopamine receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N05 PSYCHOLEPTICS
   N05A ANTIPSYCHOTICS
    N05AH Diazepines, oxazepines and thiazepines
     N05AH03 Olanzapine
      D06623  Olanzapine pamoate (USAN)
USP drug classification [BR:br08302]
 Antipsychotics
  2nd Generation/Atypical
   Olanzapine
    D06623  Olanzapine pamoate (USAN)
 Bipolar Agents
  Bipolar Agents, Other
   Olanzapine
    D06623  Olanzapine pamoate (USAN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Olanzapine
      D06623  Olanzapine pamoate (USAN)
   Dopamine
    dopamine D2-receptor
     Olanzapine
      D06623  Olanzapine pamoate (USAN)
    dopamine D3-receptor
     Olanzapine
      D06623  Olanzapine pamoate (USAN)
    dopamine D4-receptor
     Olanzapine
      D06623  Olanzapine pamoate (USAN)
   Histamine
    H1-receptor
     Olanzapine
      D06623  Olanzapine pamoate (USAN)
   Serotonin
    5-HT2A-receptor
     Olanzapine
      D06623  Olanzapine pamoate (USAN)
    5-HT2C-receptor
     Olanzapine
      D06623  Olanzapine pamoate (USAN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP1A2
   Olanzapine
    D06623  Olanzapine pamoate (USAN)
  CYP2D6
   Olanzapine
    D06623  Olanzapine pamoate (USAN)
BRITE hierarchy
Other DBs
CAS: 
221373-18-8
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        52
            1   C8y C    11.3427  -11.7361
            2   C8y C    10.4996  -10.6169
            3   C8y C    10.8416   -9.2533
            4   N4x N    12.1122   -8.6764
            5   N5x N    12.7566  -11.7665
            6   C8y C    13.3709   -9.3068
            7   C8y C    13.6543  -10.6847
            8   S2x S     9.6504   -8.5067
            9   C8y C     8.5722   -9.4089
            10  C8x C     9.0970  -10.6428
            11  C1a C     7.2332   -9.0864
            12  N1y N    10.6172  -12.9326
            13  C8x C    14.9821  -11.1260
            14  C8x C    16.0283  -10.1966
            15  C8x C    15.7450   -8.8188
            16  C8x C    14.4171   -8.3774
            17  C1x C     9.2325  -12.9729
            18  C1x C     8.5684  -14.2046
            19  N1y N     9.3030  -15.3956
            20  C1x C    10.6877  -15.4251
            21  C1x C    11.3518  -14.1236
            22  C1a C     8.6088  -16.6086
            23  C8x C    16.8979  -13.3774
            24  C8x C    16.8979  -14.7572
            25  C8x C    18.0927  -15.4470
            26  C8x C    19.2877  -14.7572
            27  C8y C    19.2877  -13.3774
            28  C8y C    18.0927  -12.6876
            29  C8y C    20.4825  -12.6876
            30  C8y C    20.4825  -11.3078
            31  C8y C    19.2877  -10.6180
            32  C8x C    18.0927  -11.3078
            33  C1b C    22.3693  -13.5166
            34  C8y C    23.9624  -12.6976
            35  C8y C    25.1320  -13.3729
            36  C8y C    26.3269  -12.6829
            37  C8x C    26.3269  -11.3032
            38  C8y C    25.1572  -10.6280
            39  C8y C    23.9623  -11.3179
            40  C8x C    25.1320  -14.7526
            41  C8x C    26.3270  -15.4424
            42  C8x C    27.5218  -14.7525
            43  C8x C    27.5218  -13.3728
            44  C6a C    19.2877   -9.2384
            45  O6a O    20.5011   -8.5377
            46  O6a O    18.1114   -8.5592
            47  C6a C    25.1570   -9.2383
            48  O6a O    23.9765   -8.5569
            49  O6a O    26.3662   -8.5399
            50  O1a O    21.6794  -10.6168
            51  O1a O    22.7422  -10.6134
            52  O0  O    22.8900  -16.5200
BOND        57
            1     3   4 1
            2     1   5 2
            3     4   6 1
            4     2   3 2
            5     5   7 1
            6     1   2 1
            7     6   7 1
            8     3   8 1
            9     8   9 1
            10    9  10 2
            11    2  10 1
            12    9  11 1
            13    1  12 1
            14    7  13 2
            15   13  14 1
            16   14  15 2
            17   15  16 1
            18    6  16 2
            19   12  17 1
            20   17  18 1
            21   18  19 1
            22   19  20 1
            23   20  21 1
            24   12  21 1
            25   19  22 1
            26   23  24 2
            27   24  25 1
            28   25  26 2
            29   26  27 1
            30   27  28 2
            31   23  28 1
            32   27  29 1
            33   29  30 2
            34   30  31 1
            35   31  32 2
            36   28  32 1
            37   29  33 1
            38   33  34 1
            39   34  35 1
            40   35  36 2
            41   36  37 1
            42   37  38 2
            43   38  39 1
            44   34  39 2
            45   35  40 1
            46   40  41 2
            47   41  42 1
            48   42  43 2
            49   36  43 1
            50   31  44 1
            51   44  45 2
            52   44  46 1
            53   38  47 1
            54   47  48 2
            55   47  49 1
            56   30  50 1
            57   39  51 1

» Japanese version   » Back

DBGET integrated database retrieval system