KEGG   DRUG: D06635Help
Entry
D06635                      Drug                                   
Name
Rilonacept (USAN/INN);
Arcalyst (TN)
Product
Formula
C9030H13932N2400O2670S74
Exact mass
201080.7512
Mol weight
201206.5291
Activity
Treatment of rheumatoid arthritis, autoinflammatory diseases, and osteoarthritis [DS:H00282]
Remark
ATC code: 
Comment
Rilonacept is IL-1 receptor fusion protein consisting of the Fc portion of human IgG1 and the human IL-1 receptor.
Indication: Cryopyrin-Associated Periodic Syndromes (CAPS)
fusion protein
Target
IL-1 [HSA:3552 3553] [KO:K04383 K04519]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04210  Apoptosis
hsa04620  Toll-like receptor signaling pathway
hsa04621  NOD-like receptor signaling pathway  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L04 IMMUNOSUPPRESSANTS
   L04A IMMUNOSUPPRESSANTS
    L04AC Interleukin inhibitors
     L04AC04 Rilonacept
      D06635  Rilonacept (USAN/INN)
USP drug classification [BR:br08302]
 Immunological Agents
  Immunomodulators
   Interleukin Blockers
    Rilonacept
     D06635  Rilonacept (USAN/INN)
Target-based classification of drugs [BR:br08310]
 Cytokines
  IL-1 family
   IL-1A [HSA:3552] [KO:K04383]
    Rilonacept [ATC:L04AC04]
     D06635  Rilonacept (USAN/INN)
   IL-1B [HSA:3553] [KO:K04519]
    Rilonacept [ATC:L04AC04]
     D06635  Rilonacept (USAN/INN)
BRITE hierarchy
Other DBs
CAS: 
501081-76-1
PubChem: 

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