KEGG   DRUG: TezampanelHelp
Entry
D06656                      Drug                                   

Name
Tezampanel (USAN);
Tezampanel hydrate
Formula
C13H21N5O2. H2O
Exact mass
297.1801
Mol weight
297.3534
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Neuropsychiatric agent
 DG01569  AMPA receptor antagonist
Activity
Anticonvulsant, Pain relief, AMPA receptor antagonist
Comment
Treatment of migraine, neuropathic pain
Target
AMPA receptor [HSA:2890 2891 2892 2893] [KO:K05197 K05198 K05199 K05200];
kainate receptor [HSA:2897 2898 2899 2900 2901] [KO:K05201 K05202 K05203 K05204 K05205]
  Pathway
Neuroactive ligand-receptor interaction
Glutamatergic synapse
Dopaminergic synapse
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Glutamate-gated cation channels
   Glutamate (ionotropic), non-NMDA
    kainate receptor
     Tezampanel
      D06656  Tezampanel (USAN)
    AMPA receptor
     Tezampanel
      D06656  Tezampanel (USAN)
BRITE hierarchy
Other DBs
CAS: 
317819-68-4
PubChem: 
LigandBox: 
KCF data Show

ATOM        21
            1   C1y C    24.8181  -24.4012
            2   N1x N    24.8181  -25.8049
            3   C1x C    26.0337  -26.5067
            4   C1y C    27.2493  -25.8049
            5   C1y C    27.2493  -24.4012
            6   C1x C    26.0337  -23.6994
            7   C1x C    28.4649  -26.5067
            8   C1x C    29.6804  -25.8049
            9   C1y C    29.6804  -24.4012
            10  C1x C    28.4649  -23.6994
            11  C6a C    23.6026  -23.6994
            12  C1b C    30.8812  -23.7079
            13  O6a O    22.4039  -24.3916
            14  O6a O    23.6025  -22.2959
            15  C1b C    32.0726  -24.3957
            16  C8y C    33.2665  -23.7063
            17  N5x N    34.4024  -24.5276
            18  N5x N    35.5384  -23.7031
            19  N5x N    35.1052  -22.3679
            20  N4x N    33.7016  -22.3673
            21  O0  O    33.8716  -26.9278
BOND        22
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    1  11 1 #Down
            13    9  12 1 #Up
            14   11  13 1
            15   11  14 2
            16   12  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   16  20 1

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