KEGG   DRUG: D06656Help
Entry
D06656                      Drug                                   

Name
Tezampanel (USAN);
Tezampanel hydrate
Formula
C13H21N5O2. H2O
Exact mass
297.1801
Mol weight
297.3534
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Treatment of migraine, neuropathic pain
Target
AMPA receptor antagonist [HSA:2890 2891 2892 2893] [KO:K05197 K05198 K05199 K05200];
kainate receptor antagonist [HSA:2897 2898 2899 2900 2901] [KO:K05201 K05202 K05203 K05204 K05205]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04724  Glutamatergic synapse
hsa04728  Dopaminergic synapse  
 
Brite
Target-based classification of drugs [BR:br08310]
 Ion channels
  Glutamate-gated cation channels
   Glutamate (ionotropic), non-NMDA
    kainate receptor
     Tezampanel
      D06656  Tezampanel (USAN)
    AMPA receptor
     Tezampanel
      D06656  Tezampanel (USAN)
BRITE hierarchy
Other DBs
CAS: 
317819-68-4
PubChem: 
LigandBox: 
KCF data Show

ATOM        21
            1   C1y C    24.8181  -24.4012
            2   N1x N    24.8181  -25.8049
            3   C1x C    26.0337  -26.5067
            4   C1y C    27.2493  -25.8049
            5   C1y C    27.2493  -24.4012
            6   C1x C    26.0337  -23.6994
            7   C1x C    28.4649  -26.5067
            8   C1x C    29.6804  -25.8049
            9   C1y C    29.6804  -24.4012
            10  C1x C    28.4649  -23.6994
            11  C6a C    23.6026  -23.6994
            12  C1b C    30.8812  -23.7079
            13  O6a O    22.4039  -24.3916
            14  O6a O    23.6025  -22.2959
            15  C1b C    32.0726  -24.3957
            16  C8y C    33.2665  -23.7063
            17  N5x N    34.4024  -24.5276
            18  N5x N    35.5384  -23.7031
            19  N5x N    35.1052  -22.3679
            20  N4x N    33.7016  -22.3673
            21  O0  O    33.8716  -26.9278
BOND        22
            1     1   2 1
            2     2   3 1
            3     3   4 1
            4     4   5 1
            5     5   6 1
            6     1   6 1
            7     4   7 1
            8     7   8 1
            9     8   9 1
            10    9  10 1
            11    5  10 1
            12    1  11 1 #Down
            13    9  12 1 #Up
            14   11  13 1
            15   11  14 2
            16   12  15 1
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  19 2
            21   19  20 1
            22   16  20 1

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