KEGG   DRUG: MotesanibHelp
Entry
D06678                      Drug                                   

Name
Motesanib;
AMG 706
Formula
C22H23N5O
Exact mass
373.1903
Mol weight
373.4509
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antineoplastic
 DG01918  Tyrosine kinase inhibitor
  DG01917  Receptor tyrosine kinase inhibitor
Remark
Chemical structure group: DG01262
Efficacy
Antineoplastic, Angiogenesis inhibitor, Receptor tyrosine kinase inhibitor
Target
PDGFR [HSA:5156 5159] [KO:K04363 K05089]
RET [HSA:5979] [KO:K05126]
VEGFR1 (FLT1) [HSA:2321] [KO:K05096]
VEGFR2 (KDR) [HSA:3791] [KO:K05098]
VEGFR3 (FLT4) [HSA:2324] [KO:K05097]
KIT (CD117) [HSA:3815] [KO:K05091]
  Pathway
hsa04010  MAPK signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04151  PI3K-Akt signaling pathway
Interaction
Drug interaction
Structure map
map07045  Antineoplastics - protein kinases inhibitors
Brite
Target-based classification of drugs [BR:br08310]
 Protein kinases
  Receptor tyrosine kinases (RTK)
   PDGFR family
    PDGFR
     D06678  Motesanib
    KIT (CD117)
     D06678  Motesanib
   VEGFR family
    VEGFR1 (FLT1)
     D06678  Motesanib
    VEGFR2 (KDR)
     D06678  Motesanib
    VEGFR3 (FLT4)
     D06678  Motesanib
   RET family
    RET
     D06678  Motesanib
BRITE hierarchy
Other DBs
CAS: 453562-69-1
PubChem: 47208329
ChEMBL: CHEMBL572881
PDB-CCD: 706[PDBj]
LigandBox: D06678
KCF data Show

ATOM        28
            1   N1b N    23.5106  -20.7610
            2   C8y C    24.7064  -21.4514
            3   C8x C    24.7065  -22.8599
            4   C8x C    25.9172  -23.5588
            5   C8y C    27.1278  -22.8598
            6   C8y C    27.1278  -21.4513
            7   C8x C    25.9171  -20.7525
            8   C1z C    28.4674  -23.2950
            9   C1x C    29.2953  -22.1555
            10  N1x N    28.4673  -21.0161
            11  C5a C    22.2850  -21.4684
            12  C8y C    21.0933  -20.7800
            13  C8y C    19.9056  -21.4656
            14  O5a O    22.2847  -22.8700
            15  C8x C    21.0933  -19.3814
            16  C8x C    19.8820  -18.6820
            17  C8x C    18.6706  -19.3814
            18  N5x N    18.6706  -20.7800
            19  C1a C    28.1054  -24.6460
            20  C1a C    29.4564  -24.2840
            21  N1b N    19.9172  -22.8701
            22  C1b C    18.7223  -23.5733
            23  C8y C    17.5190  -22.8917
            24  C8x C    17.5068  -21.4723
            25  C8x C    16.2896  -20.7833
            26  N5x N    15.0843  -21.4931
            27  C8x C    15.0965  -22.9125
            28  C8x C    16.3137  -23.6014
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     6   7 1
            7     2   7 2
            8     5   8 1
            9     8   9 1
            10    9  10 1
            11    6  10 1
            12    1  11 1
            13   11  12 1
            14   12  13 1
            15   11  14 2
            16   12  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  13 2
            21    8  19 1
            22    8  20 1
            23   13  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 2
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   23  28 2

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