KEGG   DRUG: D06678Help
Entry
D06678                      Drug                                   

Name
Motesanib;
AMG 706
Formula
C22H23N5O
Exact mass
373.1903
Mol weight
373.4509
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiangiogenesis agent
Remark
Drug group: 
Comment
angiogenesis inhibitor
Target
PDGFRA tyrosine kinase inhibitor [HSA:5156] [KO:K04363];
PDGFRB tyrosine kinase inhibitor [HSA:5159] [KO:K05089];
RET inhibitor [HSA:5979] [KO:K05126];
VEGFR1 tyrosine kinase inhibitor [HSA:2321] [KO:K05096];
VEGFR2 tyrosine kinase inhibitor [HSA:3791] [KO:K05098];
VEGFR3 tyrosine kinase inhibitor [HSA:2324] [KO:K05097];
c-KIT tyrosine kinase inhibitor [HSA:3815] [KO:K05091]
  Pathway
hsa04010  MAPK signaling pathway
hsa04020  Calcium signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04370  VEGF signaling pathway  
 
Interaction
Drug interaction
Structure map
Antineoplastics - protein kinases inhibitors
Brite
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Receptor tyrosine kinase
   RTK class III (PDGF receptor family)
    PDGFRA tyrosine kinase
     Motesanib
      D06678  Motesanib
    PDGFRB tyrosine kinase
     Motesanib
      D06678  Motesanib
   RTK class V (VEGF receptor family)
    VEGFR1 tyrosine kinase
     Motesanib
      D06678  Motesanib
    VEGFR2 tyrosine kinase
     Motesanib
      D06678  Motesanib
    VEGFR3 tyrosine kinase
     Motesanib
      D06678  Motesanib
BRITE hierarchy
Other DBs
CAS: 
453562-69-1
PubChem: 
PDB-CCD: 
LigandBox: 
KCF data Show

ATOM        28
            1   N1b N    23.5106  -20.7610
            2   C8y C    24.7064  -21.4514
            3   C8x C    24.7065  -22.8599
            4   C8x C    25.9172  -23.5588
            5   C8y C    27.1278  -22.8598
            6   C8y C    27.1278  -21.4513
            7   C8x C    25.9171  -20.7525
            8   C1z C    28.4674  -23.2950
            9   C1x C    29.2953  -22.1555
            10  N1x N    28.4673  -21.0161
            11  C5a C    22.2850  -21.4684
            12  C8y C    21.0933  -20.7800
            13  C8y C    19.9056  -21.4656
            14  O5a O    22.2847  -22.8700
            15  C8x C    21.0933  -19.3814
            16  C8x C    19.8820  -18.6820
            17  C8x C    18.6706  -19.3814
            18  N5x N    18.6706  -20.7800
            19  C1a C    28.1054  -24.6460
            20  C1a C    29.4564  -24.2840
            21  N1b N    19.9172  -22.8701
            22  C1b C    18.7223  -23.5733
            23  C8y C    17.5190  -22.8917
            24  C8x C    17.5068  -21.4723
            25  C8x C    16.2896  -20.7833
            26  N5x N    15.0843  -21.4931
            27  C8x C    15.0965  -22.9125
            28  C8x C    16.3137  -23.6014
BOND        31
            1     1   2 1
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     6   7 1
            7     2   7 2
            8     5   8 1
            9     8   9 1
            10    9  10 1
            11    6  10 1
            12    1  11 1
            13   11  12 1
            14   12  13 1
            15   11  14 2
            16   12  15 2
            17   15  16 1
            18   16  17 2
            19   17  18 1
            20   18  13 2
            21    8  19 1
            22    8  20 1
            23   13  21 1
            24   21  22 1
            25   22  23 1
            26   23  24 1
            27   24  25 2
            28   25  26 1
            29   26  27 2
            30   27  28 1
            31   23  28 2

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