KEGG   DRUG: D06880Help
Entry
D06880                      Drug                                   

Name
Lepirudin (INN);
Refludan (TN)
Product
Formula
C287H440N80O111S6
Exact mass
6974.9569
Mol weight
6979.4239
Sequence
Leu Thr Tyr Thr Asp Cys Thr Glu Ser Gly Gln Asn Leu Cys Leu Cys
Glu Gly Ser Asn Val Cys Gly Gln Gly Asn Lys Cys Ile Leu Gly Ser
Asp Gly Glu Lys Asn Gln Cys Val Thr Gly Glu Gly Thr Pro Lys Pro
Gln Ser His Asn Asp Gly Asp Phe Glu Glu Ile Pro Glu Glu Tyr Leu
Gln (Disulfide bridge: 6-14; 16-28; 22-39)
  Type
Peptide
Activity
Anticoagulant, thrombolytic agent
Remark
ATC code: 
Comment
Peptide
Direct thrombin inhibitor
Hirudin derivative
Target
thrombin inhibitor [HSA:2147] [KO:K01313]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04610  Complement and coagulation cascades
hsa04810  Regulation of actin cytoskeleton  
 
Interaction
Drug interaction
Structure map
Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AE Direct thrombin inhibitors
     B01AE02 Lepirudin
      D06880  Lepirudin (INN)
Target-based classification of drugs [BR:br08310]
 Enzymes
  Hydrolases
   thrombin
    Lepirudin
     D06880  Lepirudin (INN)
BRITE hierarchy
Other DBs
CAS: 
138068-37-8
PubChem: 
DrugBank: 

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