KEGG   DRUG: D06888Help
Entry
D06888                      Drug                                   

Name
Eptifibatide (INN);
Integrilin (TN)
Product
Formula
C35H49N11O9S2
Exact mass
831.3156
Mol weight
831.9619
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiplatelet
Remark
ATC code: 
Comment
Indication: Acute coronary syndrome
Target
glycoprotein alphaIIb/beta3 (GPIIb/IIIa) receptor antagonist [HSA:3674 3690] [KO:K06476 K06493]
  Pathway
hsa04510  Focal adhesion
hsa04512  ECM-receptor interaction  
 
Interaction
Drug interaction
Structure map
Antithrombosis agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 B BLOOD AND BLOOD FORMING ORGANS
  B01 ANTITHROMBOTIC AGENTS
   B01A ANTITHROMBOTIC AGENTS
    B01AC Platelet aggregation inhibitors excl. heparin
     B01AC16 Eptifibatide
      D06888  Eptifibatide (INN)
Target-based classification of drugs [BR:br08310]
 Others
  Cell adhesion molecules (CAMs)
   glycoprotein alpha IIb/beta3 (GPIIb/IIIa) receptor
    Eptifibatide
     D06888  Eptifibatide (INN)
BRITE hierarchy
Other DBs
CAS: 
188627-80-7
PubChem: 
DrugBank: 
LigandBox: 
KCF data Show

ATOM        57
            1   C1b C    18.7088  -13.7108
            2   C5a C    19.8059  -12.8468
            3   N1b N    21.1717  -13.1584
            4   C1c C    21.7738  -14.4120
            5   C1b C    18.7088  -15.1203
            6   C5a C    21.1726  -15.6797
            7   N1b N    19.8059  -15.9914
            8   C1b C    17.4960  -13.0106
            9   S3a S    16.2830  -13.7108
            10  N1b N    16.2830  -15.1203
            11  C5a C    17.4960  -15.8206
            12  S3a S    15.0702  -13.0106
            13  C1b C    13.8574  -13.7108
            14  C5a C    13.8574  -15.1203
            15  C1c C    15.0702  -15.8206
            16  C1c C    12.6445  -13.0106
            17  N1b N    11.4317  -13.7108
            18  C1c C    11.4317  -15.1203
            19  N1b N    12.6445  -15.8206
            20  C5a C    10.2188  -13.0106
            21  C1y C     9.0059  -13.7108
            22  N1y N     9.0059  -15.1203
            23  C5a C    10.2188  -15.8206
            24  C1x C     7.6655  -13.2753
            25  C1x C     6.8370  -14.4156
            26  C1x C     7.6655  -15.5559
            27  O5a O    19.4918  -11.4542
            28  O5a O    22.0432  -16.7652
            29  O5a O    17.4959  -17.2273
            30  O5a O    13.8573  -16.5271
            31  O5a O    10.2187  -17.2274
            32  O5a O    10.2188  -11.6254
            33  C5a C    12.6449  -11.6258
            34  C1b C    11.4318  -16.5270
            35  O5a O    13.8817  -10.9118
            36  N1a N    11.4561  -10.9388
            37  C1b C    15.0703  -17.2273
            38  C6a C    16.1138  -18.1470
            39  O6a O    17.5084  -18.1449
            40  O6a O    15.6221  -19.4512
            41  C8y C    12.5155  -17.3949
            42  C8y C    12.0831  -18.6924
            43  C8y C    13.1918  -19.5005
            44  N4x N    14.3028  -18.6958
            45  C8x C    13.8809  -17.3903
            46  C8x C    10.7241  -19.4142
            47  C8x C    10.7347  -20.8147
            48  C8x C    11.9280  -21.4916
            49  C8x C    13.1355  -20.7822
            50  C1b C    23.0144  -13.7651
            51  C1b C    24.2287  -14.5371
            52  C1b C    25.4597  -13.8950
            53  C1b C    26.6501  -14.6525
            54  N1b N    27.9233  -13.9887
            55  C2c C    29.1261  -14.7540
            56  N1a N    30.3635  -14.1090
            57  N2a N    29.1348  -16.1754
BOND        60
            1     3   4 1
            2     4   6 1
            3     2   3 1
            4     5   7 1
            5     1   2 1
            6     6   7 1
            7     1   8 1
            8     8   9 1
            9    10  11 1
            10    5  11 1
            11    9  12 1
            12   12  13 1
            13   14  15 1
            14   10  15 1
            15   13  16 1
            16   16  17 1
            17   18  19 1
            18   14  19 1
            19   17  20 1
            20   20  21 1
            21   21  22 1
            22   22  23 1
            23   18  23 1
            24   21  24 1
            25   24  25 1
            26   25  26 1
            27   22  26 1
            28    2  27 2
            29    6  28 2
            30   11  29 2
            31   14  30 2
            32   23  31 2
            33   20  32 2
            34   16  33 1
            35   18  34 1
            36   33  35 2
            37   33  36 1
            38   15  37 1
            39   37  38 1
            40   38  39 2
            41   38  40 1
            42   34  41 1
            43   41  42 1
            44   42  43 1
            45   43  44 1
            46   44  45 1
            47   41  45 2
            48   42  46 2
            49   46  47 1
            50   47  48 2
            51   48  49 1
            52   43  49 2
            53    4  50 1
            54   50  51 1
            55   51  52 1
            56   52  53 1
            57   53  54 1
            58   54  55 1
            59   55  56 1
            60   55  57 2

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