KEGG   DRUG: D06889Help
Entry
D06889                      Drug                                   

Name
Pegfilgrastim (genetical recombination) (JAN);
Pegfilgrastim (INN);
Neulasta (TN)
Product
Formula
C849H1347N223O244S9. (C2H4O)n
Sequence
MTPLGPASSL PQSFLLKCLE QVRKIQGDGA ALQEKLCATY KLCHPEELVL LGHSLGIPWA
PLSSCPSQAL QLAGCLSQLH SGLFLYQGLL QALEGISPEL GPTLDTLQLD VADFATTIWQ
QMEELGMAPA LQPTQGAMPA FASAFQRRAG GVLVASHLQS FLEVSYRVLR HLAQP
(Disulfide bridge: 37-43; 65-75)
  Type
Peptide
Activity
Immunomodulator;
Colony stimulating factor, granulocyte [DS:H00100]
Remark
ATC code: 
Comment
Indication: Febrile neutropenia
recombinant G-CSF [HSA:1440] [KO:K05423]
Target
granulocyte colony stimulating factor (G-CSF) receptor stimulant [HSA:1441] [KO:K05061]
  Pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa04630  Jak-STAT signaling pathway  
 
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 L ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
  L03 IMMUNOSTIMULANTS
   L03A IMMUNOSTIMULANTS
    L03AA Colony stimulating factors
     L03AA13 Pegfilgrastim
      D06889  Pegfilgrastim (INN)
USP drug classification [BR:br08302]
 Blood Products/Modifiers/Volume Expanders
  Blood Formation Modifiers
   Pegfilgrastim
    D06889  Pegfilgrastim (INN)
Target-based classification of drugs [BR:br08310]
 Cytokine receptors
  Class I cytokine receptors (hematopoietin family receptors)
   granulocyte colony stimulating factor (G-CSF) receptor
    Pegfilgrastim
     D06889  Pegfilgrastim (INN)
BRITE hierarchy
Other DBs
CAS: 
208265-92-3
PubChem: 
DrugBank: 

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