KEGG   DRUG: AbacavirHelp
Entry
D07057                      Drug                                   

Name
Abacavir (INN)
Formula
C14H18N6O
Exact mass
286.1542
Mol weight
286.3323
Structure
Mol fileKCF fileDB searchJmolKegDraw
Class
Antiviral
 DG01890  Nucleoside reverse transcriptase inhibitor
 DG01656  HIV reverse transcriptase inhibitor
Remark
Same as: 
ATC code: 
Chemical group: 
Activity
Antiviral, Reverse transcriptase inhibitor
Comment
Nucleoside reverse transcriptase inhibitor (NRTI)
Patients who carry the HLA-B*5701 allele are at high risk for experiencing a hypersensitivity reaction to Abacavir
Target
RNA-directed DNA polymerase
Interaction
Genomic biomarker: HLA-B [HSA:3106]
Drug interaction
Structure map
Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF06 Abacavir
      D07057  Abacavir (INN)
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)v
   Abacavir
    D07057  Abacavir (INN)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-HIV agents
   Reverse transcriptase inhibitor (RTI)
    Nucleoside and nucleotide reverse transcriptase inhibitor (NRTIs)
     Abacavir
      D07057  Abacavir (INN)
BRITE hierarchy
Other DBs
CAS: 
136470-78-5
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
KCF data Show

ATOM        21
            1   C8y C    23.8170  -14.6900
            2   C8y C    23.7804  -16.2205
            3   C8y C    25.0169  -14.0352
            4   N5x N    22.6209  -14.2394
            5   N4y N    22.5468  -16.6128
            6   N5x N    24.9874  -16.9825
            7   N1b N    24.9742  -12.6601
            8   N5x N    26.2927  -14.8134
            9   C8x C    21.7300  -15.3835
            10  C1y C    21.3918  -17.5530
            11  C8y C    26.3325  -16.2972
            12  C1y C    26.2749  -11.9849
            13  C1x C    20.2274  -16.7385
            14  C2x C    21.0014  -18.8162
            15  N1a N    27.4571  -17.0274
            16  C1x C    27.6665  -12.0101
            17  C1x C    26.9828  -10.7806
            18  C1y C    19.1513  -17.5594
            19  C2x C    19.6159  -18.8564
            20  C1b C    17.8359  -17.1879
            21  O1a O    16.7496  -18.0561
BOND        24
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 2
            9    10   5 1 #Up
            10    6  11 2
            11    7  12 1
            12   10  13 1
            13   10  14 1
            14   11  15 1
            15   12  16 1
            16   12  17 1
            17   13  18 1
            18   14  19 2
            19   18  20 1 #Up
            20   20  21 1
            21    5   9 1
            22    8  11 1
            23   16  17 1
            24   18  19 1

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