KEGG   DRUG: D07057Help
Entry
D07057                      Drug                                   

Name
Abacavir (INN)
Formula
C14H18N6O
Exact mass
286.1542
Mol weight
286.3323
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antiviral [DS:H00406]
Remark
Same as: 
ATC code: 
Drug group: 
Comment
Nucleoside reverse transcriptase inhibitor (NRTI)
Patients who carry the HLA-B*5701 allele are at high risk for experiencing a hypersensitivity reaction to Abacavir
Target
RNA-directed DNA polymerase inhibitor
Interaction
Genomic biomarker: HLA-B [HSA:3106]
Drug interaction
Structure map
Antiviral agents
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 J ANTIINFECTIVES FOR SYSTEMIC USE
  J05 ANTIVIRALS FOR SYSTEMIC USE
   J05A DIRECT ACTING ANTIVIRALS
    J05AF Nucleoside and nucleotide reverse transcriptase inhibitors
     J05AF06 Abacavir
      D07057  Abacavir (INN)
USP drug classification [BR:br08302]
 Antivirals
  Anti-HIV Agents, Nucleoside and Nucleotide Reverse Transcriptase Inhibitors (NRTI)v
   Abacavir
    D07057  Abacavir (INN)
Antiinfectives [BR:br08307]
 Antivirals
  Anti-HIV agents
   Reverse transcriptase inhibitor (RTI)
    Nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs)
     Abacavir
      D07057  Abacavir (INN)
BRITE hierarchy
Other DBs
CAS: 
136470-78-5
PubChem: 
DrugBank: 
PDB-CCD: 
LigandBox: 
KCF data Show

ATOM        21
            1   C8y C    23.8170  -14.6900
            2   C8y C    23.7804  -16.2205
            3   C8y C    25.0169  -14.0352
            4   N5x N    22.6209  -14.2394
            5   N4y N    22.5468  -16.6128
            6   N5x N    24.9874  -16.9825
            7   N1b N    24.9742  -12.6601
            8   N5x N    26.2927  -14.8134
            9   C8x C    21.7300  -15.3835
            10  C1y C    21.3918  -17.5530
            11  C8y C    26.3325  -16.2972
            12  C1y C    26.2749  -11.9849
            13  C1x C    20.2274  -16.7385
            14  C2x C    21.0014  -18.8162
            15  N1a N    27.4571  -17.0274
            16  C1x C    27.6665  -12.0101
            17  C1x C    26.9828  -10.7806
            18  C1y C    19.1513  -17.5594
            19  C2x C    19.6159  -18.8564
            20  C1b C    17.8359  -17.1879
            21  O1a O    16.7496  -18.0561
BOND        24
            1     1   2 2
            2     1   3 1
            3     1   4 1
            4     2   5 1
            5     2   6 1
            6     3   7 1
            7     3   8 2
            8     4   9 2
            9    10   5 1 #Up
            10    6  11 2
            11    7  12 1
            12   10  13 1
            13   10  14 1
            14   11  15 1
            15   12  16 1
            16   12  17 1
            17   13  18 1
            18   14  19 2
            19   18  20 1 #Up
            20   20  21 1
            21    5   9 1
            22    8  11 1
            23   16  17 1
            24   18  19 1

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