KEGG   DRUG: D07077Help
Entry
D07077                      Drug                                   

Name
Ambrisentan (JAN/INN);
Letairis (TN);
Volibris (TN)
Product
Formula
C22H22N2O4
Exact mass
378.158
Mol weight
378.4211
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Antihypertensive
Remark
Therapeutic category: 
ATC code: 
Target
endothelin receptor type A antagonist [HSA:1909] [KO:K04197]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction  
 
Metabolism
Transporter: ABCB1 [HSA:5243]
Interaction
Drug interaction
Structure map
Angiotensin receptor and endothelin receptor antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C02 ANTIHYPERTENSIVES
   C02K OTHER ANTIHYPERTENSIVES
    C02KX Other antihypertensives
     C02KX02 Ambrisentan
      D07077  Ambrisentan (JAN/INN)
USP drug classification [BR:br08302]
 Respiratory Tract/Pulmonary Agents
  Pulmonary Antihypertensives
   Ambrisentan
    D07077  Ambrisentan (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 2  Agents affecting individual organs
  21  Cardiovascular agents
   219  Miscellaneous
    2190  Miscellaneous
     D07077  Ambrisentan (JAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Endothelin
    endothelin receptor type A
     Ambrisentan
      D07077  Ambrisentan (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
177036-94-1
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   C8x C    21.6300  -20.6500
            2   C8x C    21.6300  -22.0500
            3   C8x C    22.8424  -22.7500
            4   C8x C    24.0549  -22.0500
            5   C8y C    24.0549  -20.6500
            6   C8x C    22.8424  -19.9500
            7   C1d C    25.2860  -19.9390
            8   C8y C    26.4912  -20.6347
            9   C8x C    26.4916  -22.0496
            10  C8x C    27.7042  -22.7493
            11  C8x C    28.9165  -22.0489
            12  C8x C    28.9160  -20.6339
            13  C8x C    27.7034  -19.9343
            14  O2a O    24.1597  -19.0972
            15  C1c C    26.0464  -18.7850
            16  C1a C    22.7502  -19.0885
            17  O2a O    27.4396  -18.7934
            18  C6a C    25.3743  -17.5284
            19  O6a O    23.9401  -17.4825
            20  O6a O    26.1159  -16.3347
            21  C8y C    28.1619  -17.5605
            22  N5x N    29.5400  -17.5693
            23  C8y C    30.2478  -16.3614
            24  C8x C    29.5555  -15.1445
            25  C8y C    28.1774  -15.1356
            26  N5x N    27.4697  -16.3436
            27  C1a C    31.6400  -16.3704
            28  C1a C    27.4867  -13.9213
BOND        30
            1     1   2 2
            2     2   3 1
            3     3   4 2
            4     4   5 1
            5     5   6 2
            6     1   6 1
            7     5   7 1
            8     7   8 1
            9     8   9 2
            10    9  10 1
            11   10  11 2
            12   11  12 1
            13   12  13 2
            14    8  13 1
            15    7  14 1
            16    7  15 1
            17   14  16 1
            18   15  17 1
            19   15  18 1 #Up
            20   18  19 1
            21   18  20 2
            22   17  21 1
            23   21  22 2
            24   22  23 1
            25   23  24 2
            26   24  25 1
            27   25  26 2
            28   21  26 1
            29   23  27 1
            30   25  28 1

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