KEGG   DRUG: D07124Help
Entry
D07124                      Drug                                   

Name
Alfuzosin (INN);
Xatral (TN)
Formula
C19H27N5O4
Exact mass
389.2063
Mol weight
389.4488
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Anthihypertensive: alpha-adrenergic blocking agent
Remark
ATC code: 
Drug group: 
Target
alpha1-adrenergic receptor (especially alpha-1A) agonist [HSA:148 147 146] [KO:K04135 K04136 K04137]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction
hsa04970  Salivary secretion  
 
Interaction
Drug interaction
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 G GENITO URINARY SYSTEM AND SEX HORMONES
  G04 UROLOGICALS
   G04C DRUGS USED IN BENIGN PROSTATIC HYPERTROPHY
    G04CA Alpha-adrenoreceptor antagonists
     G04CA01 Alfuzosin
      D07124  Alfuzosin (INN)
USP drug classification [BR:br08302]
 Genitourinary Agents
  Benign Prostatic Hypertrophy Agents
   Alfuzosin
    D07124  Alfuzosin (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    alpha1-adrenergic receptor
     Alfuzosin
      D07124  Alfuzosin (INN)
BRITE hierarchy
Other DBs
CAS: 
81403-80-7
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        28
            1   N5x N    26.1100   -9.5200
            2   C8y C    26.1100   -8.1200
            3   N5x N    27.3000   -7.4200
            4   C8y C    28.4900   -8.1200
            5   C8y C    28.4900   -9.5200
            6   C8y C    27.3000  -10.2200
            7   C8x C    29.7500   -7.4200
            8   C8y C    30.9400   -8.1200
            9   C8y C    30.9400   -9.5200
            10  C8x C    29.7500  -10.2200
            11  O2a O    32.1300  -10.2200
            12  C1a C    33.3200   -9.5200
            13  O2a O    32.1300   -7.4200
            14  C1a C    33.3200   -8.0500
            15  N1c N    24.8500   -7.4200
            16  C1b C    23.6600   -8.0500
            17  C1a C    24.8500   -5.9500
            18  C1b C    22.4700   -7.4200
            19  C1b C    21.2800   -8.0500
            20  N1b N    20.0900   -7.4200
            21  C5a C    18.9000   -8.0500
            22  O5a O    18.9000   -9.5200
            23  N1a N    27.3000  -11.6200
            24  C1x C    15.4000   -7.2800
            25  C1x C    15.8900   -5.9500
            26  C1x C    17.2900   -5.9500
            27  C1y C    17.7100   -7.3500
            28  O2x O    16.5200   -8.1200
BOND        30
            1     1   2 1
            2     2   3 2
            3     3   4 1
            4     4   5 2
            5     5   6 1
            6     1   6 2
            7     4   7 1
            8     7   8 2
            9     8   9 1
            10    9  10 2
            11    5  10 1
            12    9  11 1
            13   11  12 1
            14    8  13 1
            15   13  14 1
            16    2  15 1
            17   15  16 1
            18   15  17 1
            19   16  18 1
            20   18  19 1
            21   19  20 1
            22   20  21 1
            23   21  22 2
            24    6  23 1
            25   24  25 1
            26   25  26 1
            27   26  27 1
            28   27  28 1
            29   24  28 1
            30   21  27 1

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