KEGG   DRUG: D07132Help
Entry
D07132                      Drug                                   

Name
Buprenorphine (JAN/INN);
Temgesic (TN)
Product
Formula
C29H41NO4
Exact mass
467.3036
Mol weight
467.6401
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
Opioid analgesic
Remark
Same as: 
Therapeutic category: 
ATC code: 
Drug group: 
Target
kappa-opioid receptor antagonist [HSA:4986] [KO:K04214];
mu-opioid receptor partial agonist [HSA:4988] [KO:K04215]
  Pathway
hsa04080  Neuroactive ligand-receptor interaction  
 
Interaction
Drug interaction
Structure map
Opioid analgesics
Opioid receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 N NERVOUS SYSTEM
  N02 ANALGESICS
   N02A OPIOIDS
    N02AE Oripavine derivatives
     N02AE01 Buprenorphine
      D07132  Buprenorphine (JAN/INN)
  N07 OTHER NERVOUS SYSTEM DRUGS
   N07B DRUGS USED IN ADDICTIVE DISORDERS
    N07BC Drugs used in opioid dependence
     N07BC01 Buprenorphine
      D07132  Buprenorphine (JAN/INN)
USP drug classification [BR:br08302]
 Anti-Addiction/Substance Abuse Treatment Agents
  Opioid Dependence Treatments
   Buprenorphine
    D07132  Buprenorphine (JAN/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 1  Agents affecting nervous system and sensory organs
  11  Agents affecting central nervous system
   114  Antipyretics and analgesics, anti-inflammatory agents
    1149  Others
     D07132  Buprenorphine (JAN/INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Opioid
    mu-opioid receptor
     Buprenorphine
      D07132  Buprenorphine (JAN/INN)
    kappa-opioid receptor
     Buprenorphine
      D07132  Buprenorphine (JAN/INN)
BRITE hierarchy
Other DBs
CAS: 
52485-79-7
PubChem: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        34
            1   C1z C    16.5998  -15.1247
            2   C1z C    17.7863  -15.8227
            3   C1y C    15.4132  -15.8227
            4   C8y C    16.5998  -13.7986
            5   C1x C    17.7863  -14.4267
            6   C1y C    18.9729  -15.1247
            7   C1x C    17.7863  -17.2186
            8   C1x C    17.2280  -16.8697
            9   C1z C    15.4132  -17.1488
            10  O2x O    14.7851  -14.2872
            11  C8y C    15.4830  -13.1006
            12  C8y C    17.8561  -13.1006
            13  C1x C    20.1595  -14.4267
            14  N1y N    20.1595  -15.8227
            15  C1x C    18.9727  -13.7986
            16  C1y C    16.5998  -17.8468
            17  C1x C    16.0414  -16.1717
            18  C8y C    15.4830  -11.7047
            19  C8x C    17.8561  -11.7047
            20  C1b C    21.3460  -15.1945
            21  C8x C    16.6696  -11.0067
            22  O1a O    14.2965  -11.0067
            23  C1y C    22.5326  -15.8925
            24  C1x C    23.2305  -17.0790
            25  C1x C    23.9285  -15.8925
            26  O2a O    14.0173  -17.1488
            27  C1a C    13.3193  -15.9400
            28  C1d C    17.2978  -19.0557
            29  C1a C    18.6935  -19.0557
            30  C1d C    16.6094  -20.2477
            31  O1a O    17.9861  -20.2478
            32  C1a C    15.2041  -20.2478
            33  C1a C    17.2930  -21.4316
            34  C1a C    15.7619  -21.4443
BOND        40
            1     1   5 1 #Up
            2     2   6 1
            3     2   7 1
            4     2   8 1 #Down
            5     3   9 1
            6     3  10 1 #Down
            7     4  11 1
            8     4  12 2
            9     5  13 1
            10    6  14 1 #Up
            11    6  15 1
            12    7  16 1
            13    8  17 1
            14   11  18 2
            15   12  19 1
            16   14  20 1
            17   18  21 1
            18   18  22 1
            19    9  16 1
            20    9  17 1 #Down
            21   10  11 1
            22   12  15 1
            23   14  13 1 #Up
            24   19  21 2
            25    1   2 1
            26   20  23 1
            27    1   3 1
            28    1   4 1
            29   23  24 1
            30   23  25 1
            31   25  24 1
            32    9  26 1
            33   26  27 1
            34   16  28 1
            35   28  29 1 #Up
            36   28  30 1
            37   28  31 1 #Down
            38   30  32 1
            39   30  33 1
            40   30  34 1

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