KEGG   DRUG: D07156Help
Entry
D07156                      Drug                                   

Name
Alprenolol (INN)
Formula
C15H23NO2
Exact mass
249.1729
Mol weight
249.3486
Structure
Mol fileKCF fileDB searchJmolKegDraw
Activity
beta-Adrenergic blocking agent
Remark
ATC code: 
Drug group: 
Target
beta1-adrenergic receptor antagonist [HSA:153] [KO:K04141];
beta2-adrenergic receptor antagonist [HSA:154] [KO:K04142];
beta3-adrenergic receptor antagonist [HSA:155] [KO:K04143]
  Pathway
hsa04020  Calcium signaling pathway
hsa04080  Neuroactive ligand-receptor interaction
hsa04261  Adrenergic signaling in cardiomyocytes
hsa04970  Salivary secretion  
 
Metabolism
Enzyme: CYP2D6 [HSA:1565]
Interaction
Drug interaction
Structure map
Antiarrhythmic drugs
beta-Adrenergic receptor agonists/antagonists
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 C CARDIOVASCULAR SYSTEM
  C07 BETA BLOCKING AGENTS
   C07A BETA BLOCKING AGENTS
    C07AA Beta blocking agents, non-selective
     C07AA01 Alprenolol
      D07156  Alprenolol (INN)
Target-based classification of drugs [BR:br08310]
 G Protein-coupled receptors
  Rhodopsin family
   Adrenaline
    beta1-adrenergic receptor
     Alprenolol
      D07156  Alprenolol (INN)
    beta2-adrenergic receptor
     Alprenolol
      D07156  Alprenolol (INN)
    beta3-adrenergic receptor
     Alprenolol
      D07156  Alprenolol (INN)
Cytochrome P450 interactions [BR:br08309]
 Substrates
  CYP2D6
   Alprenolol
    D07156  Alprenolol (INN)
BRITE hierarchy
Other DBs
CAS: 
13655-52-2
PubChem: 
DrugBank: 
LigandBox: 
NIKKAJI: 
KCF data Show

ATOM        18
            1   C1b C    23.5900  -16.1700
            2   C1c C    24.7800  -16.8700
            3   C1b C    25.9700  -16.1700
            4   N1b N    27.1600  -16.8700
            5   C1c C    28.4200  -16.1700
            6   C1a C    29.6100  -16.8700
            7   O2a O    22.3300  -16.8700
            8   O1a O    24.7800  -18.2700
            9   C1a C    28.4200  -14.7700
            10  C8y C    22.3300  -18.2700
            11  C8y C    21.1400  -18.9700
            12  C8x C    21.1400  -20.3700
            13  C8x C    22.3300  -21.0700
            14  C8x C    23.5900  -20.3700
            15  C8x C    23.5900  -18.9700
            16  C1b C    19.9500  -18.2700
            17  C2b C    18.7600  -18.9700
            18  C2a C    18.7600  -20.3700
BOND        18
            1     2   3 1
            2     3   4 1
            3     4   5 1
            4     5   6 1
            5     2   8 1
            6     7   1 1
            7     5   9 1
            8     1   2 1
            9     7  10 1
            10   10  11 2
            11   11  12 1
            12   12  13 2
            13   13  14 1
            14   14  15 2
            15   10  15 1
            16   11  16 1
            17   16  17 1
            18   17  18 2

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